Results 41 to 50 of about 64,903 (243)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A hybrid simple exponential smoothing-barnacles mating optimization approach for parameter estimation: Enhancing COVID-19 forecasting in Malaysia

MethodsX
Single or simple exponential smoothing (SES) is a time series forecasting model popular among researchers due to its simplicity and ease of use. SES only requires one smoothing parameter, alpha, to control how quickly the influence of past observations ...
Azlan Abdul Aziz, Zuriani Mustaffa, Suzilah Ismail, Nor Azriani Mohamad Nor, Nurin Qistina Mohamad Fozi   +4 more
doaj   +1 more source

Cross-Validation, Information Theory, or Maximum Likelihood? A Comparison of Tuning Methods for Penalized Splines

Stats, 2021
Functional data analysis techniques, such as penalized splines, have become common tools used in a variety of applied research settings. Penalized spline estimators are frequently used in applied research to estimate unknown functions from noisy data ...
Lauren N. Berry, Nathaniel E. Helwig
doaj   +1 more source

Smooth Dependence of Topological Conjugacies on Parameters

Advanced Nonlinear Studies, 2011
Abstract For nonautonomous linear equations xʹ = A(t)x with a nonuniform exponential dichotomy, we show that under sufficiently small C1 parameter-dependent perturbations, namely of the form xʹ = A(t)x + f (t, x, λ), the topological conjugacies in an appropriate version of the Grobman-Hartman theorem are of class C1 in the parameter ...
Barreira, Luis, Valls, Claudia
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Coherent Targets Parameter Estimation for EVS-MIMO Radar

Remote Sensing, 2022
As an emerging technique for detection, electromagnetic vector sensor multiple-input multiple-output (EVS-MIMO) radar has attracted extensive interest recently.
Xueke Ding, Ying Hu, Changming Liu, Qun Wan   +3 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

PREDICTING THE BITCOIN PRICE USING LINEAR REGRESSION OPTIMIZED WITH EXPONENTIAL SMOOTHING

Jurnal Riset Informatika, 2021
Bitcoin is one of the most popular cryptocurrencies today. In the current pandemic conditions that hit the world due to Covid-19, bitcoin is expected to be used as an investment when the level of economic uncertainty is high. In this study, the data used
Indah Suryani, Hani Harafani
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source