Results 51 to 60 of about 11,532 (237)

Therapeutic Outcomes in VEXAS Syndrome: A Multicenter Comparative Cohort of Allogeneic Hematopoietic Stem Cell Transplantation and Hypomethylating Agents

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Hypomethylating agents (HMA) and allogeneic hematopoietic stem cell transplantation (alloHSCT) have both demonstrated remissions in VEXAS; however, comparative data is lacking. We conducted a multicenter, retrospective analysis of 66 patients diagnosed with VEXAS syndrome treated with HMA (n = 35) or alloHSCT (n = 31). Baseline characteristics
Saubia Fathima   +48 more
wiley   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

open access: yesInternational Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim   +22 more
wiley   +1 more source

Evaluation of Phantom Doping Materials in Quantitative Susceptibility Mapping

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To measure magnetic susceptibility (χ) with Quantitative Susceptibility Mapping (QSM) and evaluate its repeatability using four phantom doping materials relevant to QSM applications. Methods A cylindrical phantom was constructed containing vials of agarose gel doped with two paramagnetic materials (ferritin, USPIO) and two diamagnetic ...
Padriac Hooper   +5 more
wiley   +1 more source

Targeting fibrosis in the treatment of lower urinary tract dysfunction

open access: yesThe Journal of Pathology, EarlyView.
Abstract Benign prostatic hyperplasia (BPH) is a widely prevalent age‐associated disease that is the main contributor to lower urinary tract dysfunction (LUTD) in aging men. Although prostate fibrosis has been recognized as a contributor to BPH pathophysiology, there are not any clinically available therapeutics that target this aspect of disease ...
Ajinkya R Limkar   +6 more
wiley   +1 more source

From Flybys to Sample Return: A Review of Space Probes and Robotic Sampling Technologies for Small Bodies

open access: yesJournal of Field Robotics, EarlyView.
ABSTRACT As a crucial puzzle piece of deep space exploration, exploring small bodies can provide significant scientific insights and valuable mineral resources. Unlike missions to the Moon and Mars, small‐body missions pose distinct technical challenges, including communication delays, weak gravity, and uncertain environments. This paper reviews a full
Xin Zhang   +3 more
wiley   +1 more source

Juvenile and Pubertal Exposure to Polystyrene Nanoplastics Impairs Epididymal Structure and Sperm Quality in Mice

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are emerging environmental contaminants capable of crossing biological barriers, accumulating in tissues, and disrupting physiological pathways. The male reproductive system is particularly vulnerable during the postnatal period, a developmental window characterized by intense testicular differentiation and epididymal ...
Gabriel Magalhães Oliveira Rigo   +10 more
wiley   +1 more source

Viruses infecting soybean and molecular characterization of soybean mosaic virus isolates in the Black Sea Region of Turkiye

open access: yesKuwait Journal of Science
Many viruses are known to infect and damage soybean (Glycine max) around the world. To detect viruses and determine their incidence, surveys were conducted in soybean fields in Samsun province located in the northern part of Türkiye for four consecutive ...
doaj   +1 more source

Soybean Resistance to Soybean Mosaic Virus

open access: yesPlants, 2020
Soybean mosaic virus (SMV) occurs in all soybean-growing areas in the world and causes huge losses in soybean yields and seed quality. During early viral infection, molecular interactions between SMV effector proteins and the soybean resistance (R ...
Kristin Widyasari   +2 more
doaj   +1 more source

Verifying VHDL Designs with Multiple Clocks in SMV [PDF]

open access: yes, 2007
The paper considers the problem of model checking real-life VHDL-based hardware designs via their automated transformation to a model verifiable using the SMV model checker. In particular, model checking of asynchronous designs, i.e., designs driven by multiple clocks, is discussed.
Ales Smrcka   +5 more
openaire   +1 more source

Disparities in AI‐Based Prior Authorization for Head and Neck Reconstruction: A Large Language Model Analysis

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Large language models (LLM) are being rapidly integrated into healthcare, particularly to streamline time‐ and labor‐intensive administrative processes. However, the potential for artificial intelligence (AI) systems to demonstrate bias when employed for insurance authorization remains poorly understood.
Shannon S. Wu   +3 more
wiley   +1 more source

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