Results 1 to 10 of about 6,880 (119)

Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)? [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essential for
Ravi Tripathi, Anchala Guglani, Rujuta Ghorpade, Binghe Wang   +3 more
doaj   +4 more sources

Human Embryonic Kidney HEK293 Cells as a Model to Study SMVT-Independent Transport of Biotin and Biotin-Furnished Nanoparticles in Targeted Therapy. [PDF]

Int J Mol Sci
The aim of this study was to investigate the usefulness of human embryonic kidney HEK293 cells as a model of normal cells in biotin-mediated therapy. The expression and role of sodium multivitamin transporter (SMVT) in the uptake and accumulation of free biotin, as well as cationic and neutral biotinylated PAMAM dendrimers of the fourth generation ...
Twardowska M, Łyskowski A, Misiorek M, Szymaszek Ż, Wołowiec S, Dąbrowska M, Uram Ł.   +6 more
europepmc   +4 more sources

Biotin-mediated drug delivery: does the biotin transporter mediate uptake of biotin conjugates? [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Sodium-dependent multivitamin transporter (SMVT) is a biotin transporter over-expressed in various types of cancer cells and is commonly studied for targeted drug delivery using biotin conjugates.
Ravi Tripathi, Xiaoxiao Yang, Dongning Liu, Wen Lu, Binghe Wang   +4 more
doaj   +2 more sources

Biotin controls intestinal stem cell mitosis and host-microbiome interactions

Cell Reports, 2022
Summary: Diet is a key regulator of metabolism and interacts with the intestinal microbiome. Here, we study the role of the Drosophila intestinal stem cell (ISC)-specific biotin transporter Smvt in midgut homeostasis, infection-induced regeneration, and ...
Constantina Neophytou, Chrysoula Pitsouli   +1 more
doaj   +3 more sources

Management and outcome of different types of ventricular tachycardia associated with hypokalemia [PDF]

Heart Rhythm O2
Background: Hypokalemia is a potentially reversible cause of ventricular tachyarrhythmias (VTAs) such as polymorphic ventricular tachycardia/ventricular fibrillation (PMVT/VF) and sustained monomorphic ventricular tachycardia (SMVT).
Micaela Ebert, MD, Ines Masmoudi, MD, Mandy Flechsig, MD, Julia Mayer, MD, Stefan Ulbrich, MD, Leonhard Schleußner, MD, Thomas Gaspar, MD, Angela Zedda, MD, Axel Linke, MD, Sergio Richter, MD   +9 more
doaj   +2 more sources

Gastrointestinal bleeding risk in cirrhotic portal vein thrombosis: focus on thrombus extension to superior mesenteric vein [PDF]

BMC Gastroenterology
Background & aims Portal vein thrombosis (PVT) is a prevalent cirrhosis complication linked to gastrointestinal bleeding. This study aims to assess correlations between PVT classification and the risk of bleeding in patients with cirrhotic PVT.
Sa Lv, Hui Feng, Tianjiao Xu, Hua Tian, Haibo Wang, Dongze Li, Shaoli You, Bing Zhu   +7 more
doaj   +2 more sources

Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus [PDF]

Journal of Nutritional Biochemistry, 2008
The sodium-dependent multivitamin transporter (SMVT) is essential for mediating and regulating biotin entry into mammalian cells. In cells, biotin is covalently linked to histones in a reaction catalyzed by holocarboxylase synthetase (HCS); biotinylation of lysine 12-biotinylated histone H4 (K12Bio H4) causes gene silencing.
Janos Zempleni
exaly   +4 more sources

Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity [PDF]

American Journal of Physiology - Renal Physiology, 2016
Utilizing a conditional (intestinal-specific) knockout (cKO) mouse model, we have recently shown that the sodium-dependent multivitamin transporter (SMVT) ( SLC5A6) is the only biotin uptake system that operates in the gut and that its deletion leads to biotin deficiency.
Subrata Sabui, Abhisek Ghosal, Hamid M Said   +2 more
exaly   +3 more sources

Functional and Molecular Aspects of Biotin Uptake via SMVT in Human Corneal Epithelial (HCEC) and Retinal Pigment Epithelial (D407) Cells [PDF]

AAPS Journal, 2012
Sodium-dependent multivitamin transporter (SMVT) is a vital transmembrane protein responsible for translocating biotin and other essential cofactors such as pantothenate and lipoate. Unlike primary cultures of corneal and retinal pigment epithelial (RPE) cells, immortalized cells can be subcultured many times, yet maintain their physiological ...
Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Dhananjay Pal   +2 more
exaly   +3 more sources

Uptake of biotin by Chlamydia Spp. through the use of a bacterial transporter (BioY) and a host-cell transporter (SMVT). [PDF]

PLoS ONE, 2012
Chlamydia spp. are obligate intracellular Gram-negative bacterial pathogens that cause disease in humans and animals. Minor variations in metabolic capacity between species have been causally linked to host and tissue tropisms.
Derek J Fisher, Reinaldo E Fernández, Nancy E Adams, Anthony T Maurelli   +3 more
doaj   +4 more sources