Results 151 to 160 of about 7,646 (175)

An SMVT-targeting and peroxynitrite-activating fluorescent probe for head and neck cancer imaging and peroxynitrite detection

Sensors and Actuators B: Chemical, 2021
Abstract Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide. For better diagnosis and precise resection of HNSCC, Fluorescent probe has been developed as an ideal tool to visualize tumor sites and to detect biological molecules. However, the targeting strategies of small molecular probes are limited.
Yue Wu, Baocun Zhu, Shengyun Huang
exaly   +2 more sources

Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system

American Journal of Physiology - Renal Physiology, 2003
It has been well established that human intestinal and liver epithelial cells transport biotin via an Na+-dependent carrier-mediated mechanism. The sodium-dependent multivitamin transport (SMVT), a biotin transporter, is expressed in both cell types.
Krishnaswamy, Balamurugan, Alvaro, Ortiz, Hamid M, Said   +2 more
exaly   +3 more sources

Biotin Uptake by Rabbit Corneal Epithelial Cells: Role of Sodium-Dependent Multivitamin Transporter (SMVT)

Current Eye Research, 2006
The objective of this research was to investigate the presence of sodium-dependent multivitamin transporter (SMVT) on rabbit corneal epithelial cells.Primary cultured rabbit corneal epithelial cells (rPCECs)and freshly excised rabbit corneas were used for characterization of biotin uptake and transport, respectively.
Dhananjay Pal, Ashim K Mitra
exaly   +3 more sources

Biotin uptake by T47D breast cancer cells: Functional and molecular evidence of sodium-dependent multivitamin transporter (SMVT)

International Journal of Pharmaceutics, 2013
The objective of this study was to investigate functional and molecular evidence of carrier mediated system responsible for biotin uptake in breast cancer (T47D) cells and to delineate mechanism of intracellular regulation of this transporter. Cellular accumulation of [3H] biotin was studied in T47D and normal mammary epithelial (MCF-12A) cells ...
Aswani Dutt Vadlapudi, Ramya Krishna Vadlapatla, Dhananjay Pal   +2 more
exaly   +3 more sources

Blood-to-retina transport of biotin via Na+-dependent multivitamin transporter (SMVT) at the inner blood-retinal barrier

Experimental Eye Research, 2010
The purpose of this study was to elucidate the mechanisms of biotin transport across the inner blood-retinal barrier (inner BRB). [(3)H]Biotin transport in the retina across the inner BRB was examined using an in vivo integration plot and retinal uptake index analyses in rats. The transport mechanism was characterized using a conditionally immortalized
Shin-ichi Akanuma, Masanori Tachikawa, Ken-Ichi Hosoya   +2 more
exaly   +3 more sources

The Design for Replacement of the South Mission Valley Trunk Sewer (SMVTS)

Pipeline Engineering and Construction, 2004
The City of San Diego's South Mission Valley Trunk Sewer (SMVTS) was originally constructed in 1947, with alignment modifications made in 1959, 1960, 1969, 1979 and 1990. The trunk sewer is now located in one of the busiest areas of San Diego. The SMVTS is primarily comprised of vitrified clay pipe ranging in size from 450 to 750 mm diameter.
John H. Harris, Kevin J. Contardi, Steven M. Fitzwilliam, Mike Sayre, Clemens Wassenberg   +4 more
openaire   +1 more source

Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide

Pharmaceutical Research, 2001
To investigate the potential for delivering large peptides orally by altering their absorptive transport pathways and improving intestinal permeability. The absorptive transport of retro-inverso (R.I.-) K-Tat9 and R.I.-K(biotin)-Tat9, novel peptidic inhibitors of the Tat protein of HIV-1, and their interactions with human SMVT (hSMVT), a high affinity,
S, Ramanathan, S, Pooyan, S, Stein, P D, Prasad, J, Wang, M J, Leibowitz, V, Ganapathy, P J, Sinko   +7 more
openaire   +2 more sources

Biotinylated PAMAM dendrimers for intracellular delivery of cisplatin to ovarian cancer: role of SMVT.

Anticancer research, 2011
The aim of this study was to prepare biotinylated PAMAM dendrimers loaded with cisplatin and to evaluate the cytotoxicity in ovarian cancer cell lines.Biotinylated and unconjugated dendrimer-cisplatin complexes were investigated for encapsulation efficiency, in vitro cytotoxic activity and cellular accumulation of cisplatin in OVCAR-3, SKOV-3, A2780 ...
Venkata K, Yellepeddi, Ajay, Kumar, Diane M, Maher, Subhash C, Chauhan, Kiran K, Vangara, Srinath, Palakurthi   +5 more
openaire   +1 more source

Biotin/pantothenic acid over‐supplementation to SLC5A6 knockout (SMVT‐cKO) mice leads to normalization of the growth rate, intestinal mucosal morphology, and tight junction integrity of the knockout animals

The FASEB Journal, 2017
We have recently shown that intestinal‐specific(conditional) knockout of mouse SLC5A6 gene (which encodes sodium‐dependent multivitamin transporter, SMVT) leads to severe inhibition in intestinal biotin absorption, biotin deficiency and growth retardation.
Subrata Sabui, Nils W Lambrecht, Rubina Kapadia, Abhisek Ghosal, Hamid Said   +4 more
openaire   +1 more source

Development and implementation of a guideline-based decision support system for etiological diagnosis of Sustained Monomorphic Ventricular Tachycardia (SMVT)

European Heart Journal
Abstract Background Guideline (GL)-based decision support systems (DSSs) play a significant role in supporting physicians in their decision-making processes by providing structured clinical guidance. While these systems have shown significant success in enhancing practitioner performance and patient ...
S Zheng, X W Xu, Z Hu, M Wang, Y Yao, J Li   +5 more
openaire   +1 more source