Results 71 to 80 of about 87,742 (317)
Molecular Oncology, 2019 The epithelial–mesenchymal transition (EMT) plays a pivotal role in the conversion of early‐stage tumors into invasive malignancies. The transcription factor Snail, an extremely unstable protein whose subcellular levels are regulated by many E3 ubiquitin
Sun‐Mi Park +20 more
doaj +1 more source
Advanced Science, EarlyView.It is reported that Fn14 inhibited EOC metastasis by regulating Slug‐mediated EMT. Furthermore, Fn14 altered the subcellular localization of SIRT2 by interacting with SIRT2, leading to reduced SIRT2 shuttling into the nucleus and subsequently promoting the acetylated degradation of Slug.
Anyue Wu +9 more
wiley +1 more source
Platonic crystal with low-frequency locally resonant snail structures. Wave trapping, transmission amplification and shielding [PDF]
, 2018 We propose a new type of platonic crystal. The proposed microstructured plate includes snail resonators with low-frequency resonant vibrations. The particular dynamic effect of the resonators are highlighted by a comparative analysis of dispersion properties of homo- geneous and perforated plates.
arxiv +1 more source
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
Advanced Science, EarlyView.Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li +27 more
wiley +1 more source
New species of stygobiotic Belgrandiella from north Bulgaria (Gastropoda: Hydrobiidae)
Biologica Nyssana, 2012 A new stygobiotic species of Belgrandiella from a cave in north Bulgaria was described. Nine shells were collected by the author on 09.03.2013 at the entrance of the Water cave (Vodnata) near village of Musina, north Bulgaria, N43 13 14.9 E25 25 39.6 ...
Georgiev, D.
doaj
The introduction of marine cone snail species from the coast of the Qeshm Island, contains conotoxin palliative pain in mice [PDF]
بومشناسی آبزیان, 2019 Conotoxins are small toxic peptides that are synthesized in cone snail venom ducts. Conotoxins have analgesic effects in models animal. In this study, the analgesic effects with no toxicity of Persian Gulf cone snails, Conus coronatus, and Conus frigidus
Halimeh Rajabi +4 more
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Journal of Bioresource Management, 2020 The present study was conducted to study diversity and damage assessment of snails in cultivated crops and ornamental plants. The study revealed two types of snail species Macrochlamys indica and Indoplanorbis exustus in the study area. The sampled plots
Abu ul hassan faiz , Lariab Zahra Faiz
doaj +1 more source
Advanced Science, EarlyView.Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang +13 more
wiley +1 more source
Hydrogel‐Based Smart Materials for Wound Healing and Sensing
Aggregate, EarlyView.The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong +11 more
wiley +1 more source