Results 71 to 80 of about 118,470 (252)
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
Advanced Science, EarlyView.BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai +7 more
wiley +1 more source
Advanced Science, EarlyView.To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai +4 more
wiley +1 more source
Revista Portuguesa de Pneumologia, 2008 A aspiração de corpos estranhos é uma entidade frequente em crianças, mas rara em adultos. Os autores apresentam o caso de um adulto de 57 anos, sem comprometimento neurológico, que aspirou um caracol-das-vinhas (Helix pomatia) durante uma refeição ...
A. Santos Costa, Abel Afonso
doaj
Advanced Science, EarlyView.Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu +20 more
wiley +1 more source
Journal of Bioresource Management, 2020 The present study was conducted to study diversity and damage assessment of snails in cultivated crops and ornamental plants. The study revealed two types of snail species Macrochlamys indica and Indoplanorbis exustus in the study area. The sampled plots
Abu ul hassan faiz , Lariab Zahra Faiz
doaj +1 more source
T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease
Advanced Science, EarlyView.This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li +11 more
wiley +1 more source
New species of stygobiotic Belgrandiella from north Bulgaria (Gastropoda: Hydrobiidae)
Biologica Nyssana, 2012 A new stygobiotic species of Belgrandiella from a cave in north Bulgaria was described. Nine shells were collected by the author on 09.03.2013 at the entrance of the Water cave (Vodnata) near village of Musina, north Bulgaria, N43 13 14.9 E25 25 39.6 ...
Georgiev, D.
doaj
Valuing the Prevention of an Infestation: The Threat of the New Zealand Mud Snail in Northern Nevada [PDF]
The Truckee / Carson / Walker River Watershed in Northern Nevada is under an imminent threat of infestation by the New Zealand Mud Snail, an aquatic nuisance species with the potential to harm recreational fisheries. We combine a utility-theoretic system-
Klaus Moeltner, Allison Davis
core
MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer
Annals of Gastroenterological Surgery, EarlyView.Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li +5 more
wiley +1 more source