Results 41 to 50 of about 23,248 (260)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

open access: yesAdvanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu   +18 more
wiley   +1 more source

The temperature dependence of the acute toxicity of heavy metals (cadmium, copper and mercury) to a freshwater pond snail, Lymnae aluteola L.

open access: yesEnvironment Conservation Journal, 2012
Responses of a freshwater pulmonate snail Lymnae aluteola L. to copper, cadmium and mercury were observed at four temperatures in the range of 15.0 oC to 30.0 oC.
Sangita Das, A. K. Sharma , Tabrez Ahmad
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

open access: yesAdvanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi   +8 more
wiley   +1 more source

MOLLUSCICIDAL EFFICACY AND TOXICITY OF SOME PESTICIDES UNDER LABORATORY AND FIELD CONDITIONS [PDF]

open access: yesArab Universities Journal of Agricultural Sciences, 2006
Laboratory and field trials were carried out at Koom Hamada district and Etay El-baroud research station during 2004/ 2005 season to clarify the molluscicidal ac-tivities of the following: indoxacarb, lufenuron, Bacillus thurringiensis, kurestaci (Bt ...
Abdel-Halim K.Y.   +2 more
doaj   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

open access: yesAdvanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang   +11 more
wiley   +1 more source

The new findings of Velates snail from Eocene flysch in Goriška brda and Gračišće in Istria

open access: yesGeologija, 2006
Two specimens of Eocene snails of the species Velates perversus (Gmelin, 1791) are considered. The first was found in Lower Eocene flysch beds at the Vipol‘e locality in Gori{ka brda, and the second one in Middle Eocene flysch beds below the settlement ...
Vasja Mikuž
doaj  

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

open access: yesAdvanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou   +10 more
wiley   +1 more source

Genetic variability and identification of the intermediate snail hosts of Schistosoma mansoni

open access: yesMemorias do Instituto Oswaldo Cruz, 1998
Studies based on shell or reproductive organ morphology and genetic considerations suggest extensive intraspecific variation in Biomphalaria snails. The high variability at the morphological and genetic levels, as well as the small size of some specimens
Teofânia HDA Vidigal   +6 more
doaj   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

open access: yesAdvanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen   +7 more
wiley   +1 more source

On the safe of pesticides in controlling the terrestrial mollusc pests

open access: yesMemorias do Instituto Oswaldo Cruz, 1993
The preferred food items of the slugs Laevicaulis alte and the snails Achatina fulica were used to prepare 'poison baits'by injecting the pesticides 'Rogor'and 'Nuvan'to kill these mollusc pests.
A. Panigrahi, S. K. Raut
doaj   +1 more source

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