Results 1 to 10 of about 206,823 (277)

The chemistry of snake venom and its medicinal potential

Nature Reviews Chemistry, 2022
The fascination and fear of snakes dates back to time immemorial, with the first scientific treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt. Owing to their lethality, snakes have often been associated with images
Ana Oliveira, Matilde F Viegas, Saulo Luís Da Silva   +2 more
exaly   +2 more sources

Venom Ophthalmia and Ocular Complications Caused by Snake Venom

Toxins, 2020
Little is known about the detailed clinical description, pathophysiology, and efficacy of treatments for ocular envenoming (venom ophthalmia) caused by venom of the spitting elapid and other snakes, as well as ocular complications caused by snake venom ...
Kun-Che Chang, Yu-Kai Huang, Yen-Wen Chen, Min-Hui Chen, Anthony T. Tu, Yen-Chia Chen   +5 more
doaj   +2 more sources

Snake Venom Gland Organoids [PDF]

Cell, 2020
Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types. Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapitulate essential features of the pertinent epithelium. Here, we establish long-term expanding venom gland organoids from several snake species.
Post, Yorick, Puschhof, Jens, Beumer, Joep, Kerkkamp, Harald M, de Bakker, Merijn A G, Slagboom, Julien, de Barbanson, Buys, Wevers, Nienke R, Spijkers, Xandor M, Olivier, Thomas, Kazandjian, Taline D, Ainsworth, Stuart, Iglesias, Carmen Lopez, van de Wetering, Willine J, Heinz, Maria C, van Ineveld, Ravian L, van Kleef, Regina G D M, Begthel, Harry, Korving, Jeroen, Bar-Ephraim, Yotam E, Getreuer, Walter, Rios, Anne C, Westerink, Remco H S, Snippert, Hugo J G, van Oudenaarden, Alexander, Peters, Peter J, Vonk, Freek J, Kool, Jeroen, Richardson, Michael K, Casewell, Nicholas R, Clevers, Hans   +30 more
openaire   +8 more sources

Innovations in Snake Venom-Derived Therapeutics: A Systematic Review of Global Patents and Their Pharmacological Applications [PDF]

Toxins
Active compounds from natural sources, particularly snake venoms, are crucial for pharmaceutical development despite challenges in drug discovery. Snake venoms, historically used for medicinal purposes, contain bioactive peptides and enzymes that show ...
Diana Carolina Zona Rubio, Diana Marcela Aragón, Izabel Almeida Alves   +2 more
doaj   +2 more sources

Pharmacokinetics of Snake Venom [PDF]

Toxins, 2018
Understanding snake venom pharmacokinetics is essential for developing risk assessment strategies and determining the optimal dose and timing of antivenom required to bind all venom in snakebite patients. This review aims to explore the current knowledge of snake venom pharmacokinetics in animals and humans.
Suchaya Sanhajariya, Stephen Duffull, Geoffrey Isbister   +2 more
openaire   +4 more sources

Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview [PDF]

Pharmaceutics
Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins.
Álisson E. F. Alves, Anne B. C. Barros, Lindomara C. F. Silva, Lucas M. M. Carvalho, Graziela M. A. Pereira, Ana F. C. Uchôa, José M. Barbosa-Filho, Marcelo S. Silva, Karla P. O. Luna, Karla S. R. Soares, Francisco H. Xavier-Júnior   +10 more
doaj   +2 more sources

Computational Studies of Snake Venom Toxins

Toxins, 2017
Most snake venom toxins are proteins, and participate to envenomation through a diverse array of bioactivities, such as bleeding, inflammation, and pain, cytotoxic, cardiotoxic or neurotoxic effects.
Paola G. Ojeda, David Ramírez, Jans Alzate-Morales, Julio Caballero, Quentin Kaas, Wendy González   +5 more
doaj   +2 more sources

Description of the antipredatory head-wobble behaviour in Chilean rear-fanged snakes Tachymenis peruviana Wiegmann, 1835 and Tachymenis chilensis coronellina Werner, 1898 (Serpentes, Dipsadidae) [PDF]

Herpetozoa, 2022
In this work, we describe the first records of head-wobble behaviour for Tachymenis peruviana and T. chilensis coronellina. We analyse this behaviour (occurrence, frequency) and accompanying displays in both species. Of particular note is that T.
Claudio Reyes-Olivares, Alex Vera-Quispe, Alejandro Zúñiga, Félix A. Urra   +3 more
doaj   +3 more sources

First record of the invasive gecko, Lepidodactylus lugubris Duméril & Bibron, 1836 in mainland Chile (Squamata, Gekkonidae) [PDF]

Herpetozoa, 2020
In Chile, the presence of Mourning Gecko, Lepidodactylus lugubris Duméril & Bibron, 1836 has been recognized for Easter Island (Rapa Nui) from late 19th century. Here, we report the first observation of a juvenile specimen of L.
Felix A. Urra, Alejandro Zúñiga, Alejandro Bruno Miranda-Calle, Nel Melero   +3 more
doaj   +3 more sources

Extracellular Matrix Signals as Drivers of Mitochondrial Bioenergetics and Metabolic Plasticity of Cancer Cells During Metastasis

Frontiers in Cell and Developmental Biology, 2021
The role of metabolism in tumor growth and chemoresistance has received considerable attention, however, the contribution of mitochondrial bioenergetics in migration, invasion, and metastasis is recently being understood.
Félix A. Urra, Félix A. Urra, Sebastián Fuentes-Retamal, Sebastián Fuentes-Retamal, Charlotte Palominos, Charlotte Palominos, Yarcely A. Rodríguez-Lucart, Yarcely A. Rodríguez-Lucart, Camila López-Torres, Camila López-Torres, Ramiro Araya-Maturana, Ramiro Araya-Maturana   +11 more
doaj   +1 more source