Results 51 to 60 of about 47,755 (189)

Artemia salina Toxicity Assay: Standardization in a 24‐Well Microplate

Environmental Toxicology, EarlyView.
ABSTRACT Bioassays with Artemia sp. are widely used in aquatic, environmental, and human toxicology as an initial tool to investigate the toxicity of plant extracts, isolated compounds, drugs, and products of natural or synthetic origin. These assays allow for the estimation of the median lethal concentration (LC50) and guide subsequent studies in ...
Matheus Pires Miranda, Natalie Petrovna Semanovschi, Roseane Santos de Souza, Angélica Maria Lucchese, Luzimar Gonzaga Fernandez   +4 more
wiley   +1 more source

The Art of Anti-Snake Venom Administration in Snakebite Grade III Following Viper Snakebite in Developing Country: A Case Report

Jurnal Kedokteran Diponegoro
Snakebite remains a prior Neglected Tropical Disease in the World, especially in South-East Asia. There were many diversities in the management of snake bites based on the different levels of clinician experience.
Hapsari Kinanti, Agung Kusumanegara
doaj   +1 more source

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA₂ Dichotomy across Micrurus Venoms

Toxins, 2016
The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii was unveiled using a venomic approach, which identified ≥38 proteins belonging to only four snake venom protein families.
Libia Sanz, Davinia Pla, Alicia Pérez, Yania Rodríguez, Alfonso Zavaleta, Maria Salas, Bruno Lomonte, Juan J. Calvete   +7 more
doaj   +1 more source

‘I, Me, Myself’: Selfhood and Melancholy in the Journals of Gertrude Savile (1697–1758)

Journal for Eighteenth-Century Studies, EarlyView.
Abstract This article examines the journals of Gertrude Savile from 1727 in light of recent scholarship on early modern and eighteenth‐century melancholy. The concept had myriad associations with medicine, physiology, the imagination, and feeling, but questions remain about how melancholy during this period was considered by those outside the narrow ...
Daniel Beaumont
wiley   +1 more source

Significant Far‐Right Challenges to Australian Society? The XYZ and AustraliaOne

Australian Journal of Politics &History, EarlyView.
ABSTRACT Scholars who analyse the Australian far‐right from a criminological or security studies perspective propose that activists and groups pose ‘political’ challenges to Australian society. This paper examines the far‐right news website The XYZ and the AustraliaOne political party, and argues that claims that the far‐right may normalise ...
Timothy Lynch
wiley   +1 more source

Water Beings and Capitalist Relations in India's Sundarbans Delta

American Anthropologist, EarlyView.
ABSTRACT This article explores entanglements between water cosmologies and capitalist transformation in the Sundarbans delta of West Bengal, India. It traces how “awakened” tidal creeks have been iteratively enclosed as private fisheries from the colonial period to the present, with particular focus on the expansion of commercial aquaculture over the ...
Calynn Dowler
wiley   +1 more source

The habu genome reveals accelerated evolution of venom protein genes

Scientific Reports, 2018
Evolution of novel traits is a challenging subject in biological research. Several snake lineages developed elaborate venom systems to deliver complex protein mixtures for prey capture.
Hiroki Shibata, Takahito Chijiwa, Naoko Oda-Ueda, Hitomi Nakamura, Kazuaki Yamaguchi, Shousaku Hattori, Kazumi Matsubara, Yoichi Matsuda, Akifumi Yamashita, Akiko Isomoto, Kazuki Mori, Kosuke Tashiro, Satoru Kuhara, Shinichi Yamasaki, Manabu Fujie, Hiroki Goto, Ryo Koyanagi, Takeshi Takeuchi, Yasuyuki Fukumaki, Motonori Ohno, Eiichi Shoguchi, Kanako Hisata, Noriyuki Satoh, Tomohisa Ogawa   +23 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, EarlyView.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

A retrospective analysis of snake envenomation in the intensive care unit of a tertiary care hospital in Delhi

Journal of Acute Disease, 2019
Objective: To evaluate the epidemiology, clinical profile and treatment for patients with snake bite in the intensive care unit of our hospital. Methods: A retrospective analysis of patients with snake bite admitted to the intensive care unit of a ...
Shivali Panwar, Aashish Dang
doaj   +1 more source