Results 31 to 40 of about 5,985 (174)

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin‐based antivenom treatment on murine plasma proteome and peptidome

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
Bianca C. S. C. de Barros, Alison F. A. Chaves, Mariana S. L. C. Morone, Ana T. A. Sachetto, Marcelo L. Santoro, Oliver Schilling, Solange M. T. Serrano   +6 more
wiley   +1 more source

A Case of Naja atra Bite Complicated by Gas Gangrene Leading to Amputation: Pathogen and Management Lessons

Clinical Case Reports, Volume 14, Issue 7, July 2026.
Gas gangrene of the right upper limb following a Naja atra bite, with extensive skin necrosis and purulent discharge. ABSTRACT Gas gangrene after a Naja atra bite may be caused by Enterococcus faecalis from the snake's mouth, which is resistant to ceftriaxone.
Xuan Ci, Wei‐Wen Guo, Lei Yang, Yue Zhang, Zi‐Jing Liang, Jun‐Ting Huang   +5 more
wiley   +1 more source

Scrutinizing the Wallacean shortfall: global gaps in snake occurrence data across space and environment

Ecography, Volume 2026, Issue 7, July 2026.
Occurrence records are fundamental for ecological and evolutionary research, providing key information on species' geographic ranges. However, these records are often taxonomically, spatially, and temporally biased, requiring caution in their use. Here, we analysed the spatial coverage of occurrence records for over 3500 snake species worldwide to ...
Lívia Frateles, Cristina Ronquillo, Gabriel Nakamura, José Alexandre Felizola Diniz‐Filho, Richard James Ladle, Joaquín Hortal   +5 more
wiley   +1 more source

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1403-1426, July 2026.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model

Toxins
Snakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models, severe local envenoming, defined by morbidity-causing local tissue necrosis, remains poorly ...
Jaffer Alsolaiss, Gail Leeming, Rachael Da Silva, Nessrin Alomran, Nicholas R. Casewell, Abdulrazaq G. Habib, Robert A. Harrison, Cassandra M. Modahl   +7 more
doaj   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

eLife
Snakebite globally claims more than 100,000 lives per year and results in morbidity for 400,000 survivors. Current treatment uses antibody-based antivenoms which are constrained by their efficacy, safety, and cost. In this study we evaluated the efficacy
Rachel H Clare, Adam Westhorpe, Emma Stars, Taline D Kazandjian, Laura-Oana Albulescu, Stefanie K Menzies, Nicholas R Casewell   +6 more
doaj   +1 more source

Current Status and Influencing Factors of Snakebite Diagnosis and Treatment Knowledge Among Medical Staff in China: A Cross-Sectional Study

International Journal of Public Health, 2023
Objectives: This study aimed to determine the current status of the knowledge of diagnosis and treatment of snakebites among medical staff in China and its influencing factors.Methods: A cross-sectional survey of 12,581 medical staff was conducted in 12 ...
Yanlan Hu, Chuanzhu Lv, Chuanzhu Lv, Chuanzhu Lv, Xingyue Song, Yong Gan, Juntao Wang, Juntao Wang, Wenjie Hao, Wenjie Hao, Lanfen He, Lanfen He, Yu Chen, Xiaotong Han, Shijiao Yan, Shijiao Yan, Shijiao Yan   +16 more
doaj   +1 more source

A sensory ecology approach to understanding snakebites: Influence of sensory cues on the strike of the lancehead pitviper

Journal of Zoology, Volume 329, Issue 3, Page 237-246, July 2026.
Snakes are notable for having a broad range of predators and one of the most diverse repertoires of defensive behaviors. During heightened responses to aversive stimuli, one of the behaviors displayed is the venomous bite, particularly relevant because it triggers snakebite incidents in humans.
J. M. Alves‐Nunes, A. Fellone, R. H. Willemart, O. A. V. Marques   +3 more
wiley   +1 more source

Long-term health effects perceived by snakebite patients in rural Sri Lanka: A cohort study.

PLoS Neglected Tropical Diseases, 2022
The acute effects of snakebite are often emphasized, with less information on long-term effects. We aimed to describe the long-term health effects perceived by patients followed up after confirmed snakebites.
Subodha Waiddyanatha, Anjana Silva, Kosala Weerakoon, Sisira Siribaddana, Geoffrey K Isbister   +4 more
doaj   +1 more source