Results 21 to 30 of about 10,804 (180)

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms

Toxins, 2022
Snakebite envenoming is a life threatening neglected tropical disease that represents a considerable public health concern in the tropics. Viperid snakes of the genus Bothrops are among those of greatest medical importance in Latin America, and they ...
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R. Casewell   +3 more
doaj   +1 more source

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

Toxins, 2022
Snake envenoming causes rapid systemic and local effects that often result in fatal or long-term disability outcomes. It seems likely that acute phase and inflammatory responses contribute to these haemorrhagic, coagulopathic, neurotoxic, nephrotoxic and
Jaffer Alsolaiss, Chloe A. Evans, George O. Oluoch, Nicholas R. Casewell, Robert A. Harrison   +4 more
doaj   +1 more source

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Nature Communications, 2020
Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-
Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Charlotte A. Dawson, Rowan Softley, Keirah E. Bartlett, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell   +10 more
doaj   +1 more source

gerardommc/Snakebite-zoonotic-transmission: Prerelease version

, 2021
Preprint version of snakebite as a ...
g3rard0ip
core   +1 more source

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy. [PDF]

Ann N Y Acad Sci
Snakebite envenoming therapy is evolving from plasma‐derived antivenoms toward rationally engineered therapeutics. Advances in toxicovenomics, structural biology, antibody engineering, computational protein design, recombinant expression, small‐molecule inhibitors, and diagnostics are enabling toxin‐centric development of safer, more effective, and ...
Laustsen AH.
europepmc   +2 more sources

fischuu/Snakebite-GBS: Pipeline release version 0.18.3

, 2023
Defined a new Pipeline name: "Snakebite-GBS" .
Daniel Fischer
core   +1 more source

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

Nature Communications, 2023
Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven R. Hall, Sean A. Rasmussen, Edouard Crittenden, Charlotte A. Dawson, Keirah E. Bartlett, Adam P. Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R. Casewell   +9 more
doaj   +1 more source

Early online

South African Medical Journal, 2023
This article explores the management of snakebite to vulnerable patient groups, namely children and pregnant women as well as providing detail on the current best practice when caring for venom ophthalmia and surgical wounds resulting from snakebite ...
T Hardcastle, A Engelbrecht, V Lalloo, C Bell, M Toubkin, F Motara, M Kajee   +6 more
doaj   +1 more source

Community members with a history of snakebite and healthcare workers’ ranking of challenges associated with snakebite.

, 2023
Community members with a history of snakebite and healthcare workers’ ranking of challenges associated with snakebite.
Evie Prokesh (16632441), David G. Lalloo (6671252), Ymkje Stienstra (51284), Jörg Blessmann (8587155), Sofanne J. Ravensbergen (2657356), Austin Gideon Adobasom-Anane (16632444), John Humphrey Amuasi (12602330), Alexis Beyuo (12602336), Benno Kreuels (86071), Chrisantus Danaah Dari (10661573), Melvin Katey Agbogbatey (12602339), Kabiru Mohammed Abass (10661576), Leslie Mawuli Aglanu (10661570)   +12 more
core   +1 more source

Agriculture and snakebite in Bahia, Brazil – An ecological study [PDF]

, 2016
This study investigated the correlation between the incidence of snakebite and indicators of agricultural development in municipal districts of the State of Bahia, Brazil.
Yukari F Mise, Figueroa Mise, Yukari, Fernando M Carvalho, Rejâne M Lira-da-Silva, Martins Carvalho, Fernando, Maria Lira-da-Silva, Rejâne   +5 more
core   +2 more sources