Results 11 to 20 of about 10,435 (209)

Global mortality of snakebite envenoming between 1990 and 2019 [PDF]

Nature Communications, 2022
Snakebite envenoming is a leading cause of mortality among neglected tropical diseases. Here, the authors analyze a global data repository and estimate that snakebite envenoming caused over 63,000 deaths in 2019, primarily concentrated in South Asia and ...
GBD 2019 Snakebite Envenomation Collaborators
doaj   +2 more sources

Snakebite envenoming [PDF]

Nature Reviews Disease Primers, 2017
Snakebite envenoming is a neglected tropical disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions.
Gutiérrez, J, Calvete, J, Habib, A, Harrison, R, Williams, D, Warrell, D   +5 more
core   +8 more sources

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy. [PDF]

Ann N Y Acad Sci
Snakebite envenoming therapy is evolving from plasma‐derived antivenoms toward rationally engineered therapeutics. Advances in toxicovenomics, structural biology, antibody engineering, computational protein design, recombinant expression, small‐molecule inhibitors, and diagnostics are enabling toxin‐centric development of safer, more effective, and ...
Laustsen AH.
europepmc   +2 more sources

Causal inference unveils how forest coverage mitigates excess snakebite cases during rainfall seasons in Colombia

Scientific Reports
Snakebite envenoming is a neglected tropical disease that affects mainly rural populations, where antivenom is scarce. Understanding environmental drivers of snakebite incidence is critical for public health preparedness.
Juan David Gutiérrez, Carlos Bravo-Vega, Juan Manuel Cordovez   +2 more
doaj   +2 more sources

A global core outcome measurement set for snakebite clinical trials [PDF]

, 2022
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome ...
Casewell, Nicholas R., Bammigatti, C, Gerardo, CJ, Harrison, R. A., Abouyannis, Michael, Coldiron, ME, Martins, D, Harrison, Robert A, Aggarwal, D, Coldiron, Matthew E., Walker, S. A, Lamb, Thomas, Lalloo, David G, Alcoba, Gabriel, Ribeiro, Isabela, Yeri, BK, Watson, James A., Ngama, M., Ngama, Mwanajuma, Walker, AS, Isbister, Geoffrey, Hamaluba, M, Walker, Ann Sarah, Yeri, B. K., Watson, J. A., Habib, Abdulrazaq G., Casewell, Nicholas R, Lamb, T, Coldiron, Matthew E, Lewin, MR, Martins, Diogo, Hamaluba, M., Chippaux, Jean-Philippe, Ribeiro, I., Walker, Ann, Carter, RW, de Silva, H. Janaka, Yeri, Betty K., Monteiro, W, Isbister, Geoffrey K., Lewin, Matthew R., Stienstra, Ymkje, Snakebite Global Core Outcome SetStudy Group, Walker, Sarah A, Williams, D. J., Mwalukore, Salim, Chippaux, Jean-Phillippe, Alphan, HJ, Lalloo, David, Mwalukore, S., Watson, James A, Harrison, Robert A., Abouyannis, M, Cammack, N., Walker, A. Sarah, Ngama, M, Carter, Rebecca W., Bammigatti, Chanaveerappa, Hamaluba, Mainga, Gutierrez, Jose M, Williams, David J., Williams, David, Cammack, N, Habib, Abdulrazaq, Lalloo, David; id_orcid, Aggarwal, Dinesh, Lavonas, Eric, Alcoba, G, Alphan, Hassan J., Habib, AG, Esmail, H., Esmail, Hanif, Habib, Abdulrazaq Garba, Habib, A. G., Ibister, Geoffrey K, Mumba, N., Cammack, Nick, Lalloo, DG, Mumba, Noni, Casewell, NR, Alcoba Wright, Gabriel, Williams, DJ, Alcoba, G., Isbister, G. K., Lavonas, EJ, Stienstra, Y, Lavonas, E. J., Gutiérrez, José M., Yeri, Betty, Esmail, H, Mumba, N, Chippaux, Jean Philippe, Gutiérrez, J. M., Williams, David J, de Silva, HJ, Lalloo, David G., Alphan, H. J., Monteiro, Wuelton, Mwalukore, S, Yeri, Betty K, Mwangudzah, H., Martins, D., Habib, Abdulrazaq G, Lalloo, D. G., Walker, SA, Ribeiro, I, Alphan, Hassan, Casewell, N. R., Watson, JA, Alphan, Hassan J, Lavonas, Eric J., Walker, Sarah A., Aggarwal, D., Abouyannis, M., Casewell, Nick; id_orcid, Harrison, RA, Coldiron, Matthew, Mwangudzah, Hope, Harrison, Robert, Gerardo, Charles J., Gutiérrez, JM, Isbister, Geoffrey K, Isbister, GK, Chippaux, JP, Lavonas, Eric J, Mwangudzah, H, Coldiron, M. E., Guitierrez, Jose M, Gutiérrez, José María   +128 more
core   +1 more source

Physiological constraints dictate toxin spatial heterogeneity in snake venom glands

BMC Biology, 2022
Background Venoms are ecological innovations that have evolved numerous times, on each occasion accompanied by the co-evolution of specialised morphological and behavioural characters for venom production and delivery.
Taline D. Kazandjian, Brett R. Hamilton, Samuel D. Robinson, Steven R. Hall, Keirah E. Bartlett, Paul Rowley, Mark C. Wilkinson, Nicholas R. Casewell, Eivind A. B. Undheim   +8 more
doaj   +1 more source

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms

Toxins, 2022
Snakebite envenoming is a life threatening neglected tropical disease that represents a considerable public health concern in the tropics. Viperid snakes of the genus Bothrops are among those of greatest medical importance in Latin America, and they ...
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R. Casewell   +3 more
doaj   +1 more source

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

Toxins, 2022
Snake envenoming causes rapid systemic and local effects that often result in fatal or long-term disability outcomes. It seems likely that acute phase and inflammatory responses contribute to these haemorrhagic, coagulopathic, neurotoxic, nephrotoxic and
Jaffer Alsolaiss, Chloe A. Evans, George O. Oluoch, Nicholas R. Casewell, Robert A. Harrison   +4 more
doaj   +1 more source

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Nature Communications, 2020
Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-
Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Charlotte A. Dawson, Rowan Softley, Keirah E. Bartlett, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell   +10 more
doaj   +1 more source

gerardommc/Snakebite-zoonotic-transmission: Prerelease version

, 2021
Preprint version of snakebite as a ...
g3rard0ip
core   +1 more source