Results 11 to 20 of about 5,985 (174)

Severe Pediatric Snakebite With Coagulopathy and Compartment Syndrome: Conservative Management With Plasma Exchange. [PDF]

Clin Case Rep
Therapeutic plasma exchange was successfully used in a child with severe snakebite envenomation complicated by refractory venom‐induced consumptive coagulopathy and suspected compartment syndrome, leading to full recovery and avoidance of surgical intervention.
Al Muqbel ZM, Al-Majmuei A, Haider Ali A, Fahad NY, Ajjawi R, Al Dailami A, Lone A, Al Maskati M, Mohamed Mansoor N.   +8 more
europepmc   +2 more sources

Diagnosing Syndrome-Like Microangiopathic Hemolytic Anemia After Pit Viper Envenomation: Overcoming Laboratory Gaps in a Resource-Limited Setting: A Case Report From Nepal. [PDF]

Clin Case Rep
ABSTRACT Snakebite envenomation remains a significant yet often overlooked health challenge in Nepal, particularly in its rural and hilly regions. While venom‐induced consumption coagulopathy (VICC) is commonly observed with viper bites, microangiopathic hemolytic anemia (MAHA) is an extremely rare complication, especially with green pit vipers ...
Kaphle P, Gupta P, Shrestha S, Diyali N, Koirala RK, Shrestha A, Giri D, Pahari N, Sah AK, Hamal K, Bohara S.   +10 more
europepmc   +2 more sources

Physiological constraints dictate toxin spatial heterogeneity in snake venom glands

BMC Biology, 2022
Background Venoms are ecological innovations that have evolved numerous times, on each occasion accompanied by the co-evolution of specialised morphological and behavioural characters for venom production and delivery.
Taline D. Kazandjian, Brett R. Hamilton, Samuel D. Robinson, Steven R. Hall, Keirah E. Bartlett, Paul Rowley, Mark C. Wilkinson, Nicholas R. Casewell, Eivind A. B. Undheim   +8 more
doaj   +1 more source

Delays, fears and training needs: Perspectives of health workers on clinical management of snakebite revealed by a qualitative study in Kitui County, Kenya

Toxicon: X, 2021
Key aims of the WHO Strategy to halve snakebite morbidity and mortality include health system strengthening and training of health workers. This requires knowledge of local health system needs and capacity, health worker training needs, and factors ...
Kieran Barnes, Cecelia Ngari, Stanley Parkurito, Leo Wood, Denis Otundo, Robert Harrison, George O. Oluoch, Anna Trelfa, Clare Baker   +8 more
doaj   +1 more source

Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms

Toxins, 2022
Snakebite envenoming is a life threatening neglected tropical disease that represents a considerable public health concern in the tropics. Viperid snakes of the genus Bothrops are among those of greatest medical importance in Latin America, and they ...
Jaffer Alsolaiss, Nessrin Alomran, Laura Hawkins, Nicholas R. Casewell   +3 more
doaj   +1 more source

Profiling the Murine Acute Phase and Inflammatory Responses to African Snake Venom: An Approach to Inform Acute Snakebite Pathology

Toxins, 2022
Snake envenoming causes rapid systemic and local effects that often result in fatal or long-term disability outcomes. It seems likely that acute phase and inflammatory responses contribute to these haemorrhagic, coagulopathic, neurotoxic, nephrotoxic and
Jaffer Alsolaiss, Chloe A. Evans, George O. Oluoch, Nicholas R. Casewell, Robert A. Harrison   +4 more
doaj   +1 more source

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Nature Communications, 2020
Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-
Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Charlotte A. Dawson, Rowan Softley, Keirah E. Bartlett, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell   +10 more
doaj   +1 more source

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

Nature Communications, 2023
Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven R. Hall, Sean A. Rasmussen, Edouard Crittenden, Charlotte A. Dawson, Keirah E. Bartlett, Adam P. Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R. Casewell   +9 more
doaj   +1 more source

Early online

South African Medical Journal, 2023
This article explores the management of snakebite to vulnerable patient groups, namely children and pregnant women as well as providing detail on the current best practice when caring for venom ophthalmia and surgical wounds resulting from snakebite ...
T Hardcastle, A Engelbrecht, V Lalloo, C Bell, M Toubkin, F Motara, M Kajee   +6 more
doaj   +1 more source

Global mortality of snakebite envenoming between 1990 and 2019

Nature Communications, 2022
Snakebite envenoming is a leading cause of mortality among neglected tropical diseases. Here, the authors analyze a global data repository and estimate that snakebite envenoming caused over 63,000 deaths in 2019, primarily concentrated in South Asia and ...
GBD 2019 Snakebite Envenomation Collaborators
doaj   +1 more source