Results 61 to 70 of about 21,505 (292)

Delays, fears and training needs: Perspectives of health workers on clinical management of snakebite revealed by a qualitative study in Kitui County, Kenya

Toxicon: X, 2021
Key aims of the WHO Strategy to halve snakebite morbidity and mortality include health system strengthening and training of health workers. This requires knowledge of local health system needs and capacity, health worker training needs, and factors ...
Kieran Barnes, Cecelia Ngari, Stanley Parkurito, Leo Wood, Denis Otundo, Robert Harrison, George O. Oluoch, Anna Trelfa, Clare Baker   +8 more
doaj  

Antibodies as Snakebite Antivenoms: Past and Future

Toxins, 2022
Snakebite envenomation is considered a neglected tropical disease, affecting tens of thousands of people each year. The recommended treatment is the use of antivenom, which is composed of immunoglobulins or immunoglobulin fragments obtained from the ...
W. Dias da Silva, S. A. de Andrade, Â. Megale, Daniel Alexandre de Souza, O. Sant'Anna, F. Magnoli, F. Guidolin, K. Godoi, Lucas Yuri Saladini, P. Spencer, F. Portaro   +10 more
semanticscholar   +1 more source

Exploring the Utility of ssDNA Aptamers Directed against Snake Venom Toxins as New Therapeutics for Snakebite Envenoming

Toxins, 2022
Snakebite is a neglected tropical disease that causes considerable death and disability in the tropical world. Although snakebite can cause a variety of pathologies in victims, haemotoxic effects are particularly common and are typically characterised by
Nessrin Alomran, Raja Chinnappan, Jaffer Alsolaiss, N. Casewell, M. Zourob   +4 more
semanticscholar   +1 more source

Current Status and Influencing Factors of Snakebite Diagnosis and Treatment Knowledge Among Medical Staff in China: A Cross-Sectional Study

International Journal of Public Health, 2023
Objectives: This study aimed to determine the current status of the knowledge of diagnosis and treatment of snakebites among medical staff in China and its influencing factors.Methods: A cross-sectional survey of 12,581 medical staff was conducted in 12 ...
Yanlan Hu, Chuanzhu Lv, Chuanzhu Lv, Chuanzhu Lv, Xingyue Song, Yong Gan, Juntao Wang, Juntao Wang, Wenjie Hao, Wenjie Hao, Lanfen He, Lanfen He, Yu Chen, Xiaotong Han, Shijiao Yan, Shijiao Yan, Shijiao Yan   +16 more
doaj   +1 more source

A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins [PDF]

, 2018
Antivenoms developed from the plasma of hyperimmunized animals are the only effective treatment available against snakebite envenomation but shortage of supply contributes to the high morbidity and mortality toll of this tropical disease.
Arnold, Beerli, Bendandi, Bolanos, Chippaux, Elena, Frauches, Gene, Graham, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Gutierrez, Harrison, Julve, Laustsen, Laustsen, Lavonas, Marillonnet, Marillonnet, Paul, Paul, Pla, Qiu, Ramos, Rasmussen, Sarrion-Perdigones, Segura, Soller, Stock, Stoger, Syller, Theakston, Walwyn, Wang, Zheng   +38 more
core   +2 more sources

A mechanistic model of snakebite as a zoonosis: Envenoming incidence is driven by snake ecology, socioeconomics and its impacts on snakes

PLoS Neglected Tropical Diseases, 2022
Snakebite is the only WHO-listed, not infectious neglected tropical disease (NTD), although its eco-epidemiology is similar to that of zoonotic infections: envenoming occurs after a vertebrate host contacts a human. Accordingly, snakebite risk represents
Gerardo Martín, J. Erinjery, D. Ediriweera, H. J. de Silva, D. Lalloo, T. Iwamura, K. Murray   +6 more
semanticscholar   +1 more source

Snakebite envenoming: A systematic review and meta-analysis of global morbidity and mortality

PLoS Neglected Tropical Diseases
Background Snakebite envenoming represents a significant and often neglected public health challenge, particularly in rural communities across tropical and subtropical regions.
A. Afroz, B. N. Siddiquea, Hasina Akhter Chowdhury, Timothy Nw Jackson, Andrew D Watt   +4 more
semanticscholar   +1 more source

TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

Wellcome Open Research, 2022
Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only available treatment is antivenom, which has many shortcomings including high cost, intravenous administration, and high risk of adverse ...
Michael Abouyannis, R. Fitzgerald, Mwanajuma Ngama, H. Mwangudzah, Yvonne K. Nyambura, Samson Ngome, D. Riako, Lawrence Babu, Frida Lewa, L. Else, Sujan Dily Penchala, B. Orindi, Noni Mumba, Betty Kalama, F. Ndungu, I. Adetifa, S. Khoo, D. Lalloo, N. Casewell, M. Hamaluba   +19 more
semanticscholar   +1 more source

Analysis of snakebite data in Volta and Oti Regions, Ghana, 2019 [PDF]

, 2021
Introduction: globally about 5.4 million people are affected by snakebite annually leading to 2.7 million cases of snakebite envenoming and 81,000-138,000 deaths.
Abdoulie Taal, Baba Ceesay, David Agbope, Ernest Kenu, Magdalene Akos Odikro, Momodou Kalisa   +5 more
core   +1 more source

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors

Frontiers in Pharmacology
Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a ...
R. Clare, Charlotte A. Dawson, Adam P. Westhorpe, Laura-Oana Albulescu, Christopher M Woodley, Nada Mosallam, Daniel J. W. Chong, Jeroen Kool, Neil G Berry, Paul M O'Neill, N. Casewell   +10 more
semanticscholar   +1 more source