Results 41 to 50 of about 26,502 (258)

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +2 more sources

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Reproductive biology of Psomophis genimaculatus (Boettger 1885) (Serpentes: Dipsadidae) from Brazil [PDF]

Anais da Academia Brasileira de Ciências
Although the geographic distribution, phylogeny and natural history of Psomophis genimaculatus, a snake that inhabits diverse environments, such as the Chiquitana Forest, Cerrado, Pantanal, and Chaco, have been investigated in several studies ...
KELVIN Y. MORI, CECÍLIA M. FERRACINI, LILIANA PIATTI, HUGO CABRAL, VANDA LÚCIA FERREIRA   +4 more
doaj   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

High prevalence and pathogenicity of Cryptosporidium serpentis in snakes in southern China

Current Research in Parasitology and Vector-Borne Diseases
In southern China, snakes have cultural and economic significance, serving both as traditional dietary resources and as increasingly popular pets. However, the prevalence and clinical impacts of Cryptosporidium spp.
Falei Li, Xinrui Wang, Lihua Xiao, Yaoyu Feng, Yaqiong Guo   +4 more
doaj   +1 more source

Reptiles of the Atacama Region, northern Chile: localities, and representation in provinces, ecogeographic landscapes, vegetation formations and protected areas

Gayana, 2023
We provide a checklist of reptiles distributed throughout the Atacama Region, northern Chile. Twenty- two species were found inhabiting this region, and their representation in provinces, ecogeographic landscapes, vegetation formations and protected ...
Jorge Mella Ávila, Yery Marambio-Alfaro
doaj  

To Snake or Not to Snake in the Planar Swift–Hohenberg Equation

SIAM Journal on Applied Dynamical Systems, 2010
In this paper, based on their previous study of snakes-and-ladders bifurcation structures of one-dimensional Swift-Hohenberg equation, the authors extended their investigation to the two-dimensional Swift-Hohenberg equation posed on a cylinder and the plane.
Daniele Avitabile, David J. B. Lloyd, John Burke, Edgar Knobloch, Björn Sandstede   +4 more
openaire   +4 more sources

A Worm‐Inspired Origami Robot with Multimodal Locomotion for Adaptive Mobility in Complex Pipeline Environments

Advanced Science, EarlyView.
An origami worm‐inspired robot achieves multimodal locomotion in confined pipelines through mechatronic integration that embeds actuation, control, and communication within each origami module. Large, reversible configuration and dimensional changes enable 25 gaits synthesized by a unified framework across peristaltic, inchworm, and wheel‐rolling modes
Qiwei Zhang, Kangning Tan, Zihan He, Hongsen Pang, Yanjie Wang, Hongbin Fang, Jian Xu   +6 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Occurrences of the brown colour form of Western Whip (Hierophis viridiflavus carbonarius (Bonaparte, 1833)) in Slovenia

Natura Sloveniae, 2011
This article presents the first documented records of brown coloured adults of Hierophis viridiflavus carbonarius in Slovenia, and overviews some of the historical notes on unconfirmed sightings of Hierophis gemonensis in the same area of distribution.
Tomaž Jagar, Erika Ostanek
doaj   +1 more source