Results 141 to 150 of about 29,293 (286)
Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni +7 more
wiley +1 more source
SNARE proteins underpin insulin-regulated GLUT4 traffic.
, 2011 Delivery of the glucose transporter, GLUT4 from an intracellular location to the cell surface in response to insulin represents a specialised form of membrane traffic, known to be impaired in the disease states of insulin-resistance and Type-2 diabetes ...
Nia J. Bryant +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms. [PDF]
Cell Mol Neurobiol, 2023 Brolin E +3 more
europepmc +1 more source
Hydrogel Microtube Drug Carrier for Catheter‐Based Intravascular Therapy
Advanced Healthcare Materials, EarlyView.This paper proposes hydrogel microtube carriers composed of barium alginate gel, enabling long‐term vascular retention without interrupting blood flow. Intravascular treatments have long been attracting attention for therapeutic efficacy, yet practical delivery methods remained unestablished.
Shota Sato +8 more
wiley +1 more source
A GHKNN model based on the physicochemical property extraction method to identify SNARE proteins. [PDF]
Front Genet, 2022 Gu X, Ding Y, Xiao P, He T.
europepmc +1 more source
Molecular mechanisms of caseins exocytosis: role of the SNARE proteins
, 2009 National audienceThe mammary gland (MG) is a complex tissue which function is to ensure the offspring’s feeding by producing and secreting the milk components during lactation. In addition to stimulate the synthesis of the main milk proteins, the caseins,
Chanat, Eric +3 more
core
Structural Disorder Provides Increased Adaptability for Vesicle Trafficking Pathways
, 2013 Vesicle trafficking systems play essential roles in the communication between the organelles of eukaryotic cells and also between cells and their environment.
Peter Tompa +11 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez +8 more
wiley +1 more source