Uncovering the Mechanisms of Intracellular Membrane Trafficking by Reconstituted Membrane Systems [PDF]
MembranesIntracellular membrane trafficking that transports proteins, lipids, and other substances between organelles is crucial for maintaining cellular homeostasis and signal transduction. The imbalance of membrane trafficking leads to various diseases.
Shuhan Chen, Yinghui Liu, Haijia Yu
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Membrane Trafficking in Plant Immunity [PDF]
Molecular Plant, 2017 Plants employ sophisticated mechanisms to interact with pathogenic as well as beneficial microbes. Of those, membrane trafficking is key in establishing a rapid and precise response. Upon interaction with pathogenic microbes, surface-localized immune receptors undergo endocytosis for signal transduction and activity regulation while cell wall ...
Gu, Yangnan +2 more
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LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. [PDF]
PLoS ONE, 2014 Polarization of hepatocytes is manifested by bile canalicular network formation and activation of LKB1 and AMPK, which control cellular energy metabolism.
László Homolya +8 more
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Differences in the signaling pathways of α1A- and α1B-adrenoceptors are related to different endosomal targeting [PDF]
, 2013 Aims: To compare the constitutive and agonist-dependent endosomal trafficking of α1A- and α1B-adrenoceptors (ARs) and to establish if the internalization pattern determines the signaling pathways of each subtype.
A Hirasawa +54 more
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Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism
Nature Communications, 2023 Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connects to AD ...
Zoë P. Van Acker +11 more
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Structure of the bacterial flagellar hook cap provides insights into a hook assembly mechanism
Communications Biology, 2021 Matsunami et al determine the structure of the flagellar hook cap from Salmonella enterica by X-ray crystallography. The 3.3 Å resolution structure in combination with mutagenesis analysis provides insights into a putative hook assembly mechanism.
Hideyuki Matsunami +4 more
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VAMP5 and distinct sets of cognate Q-SNAREs mediate exosome release
Cell Structure and Function, 2023 Small extracellular vesicles (sEVs) are largely classified into two types, plasma-membrane derived sEVs and endomembrane-derived sEVs. The latter type (referred to as exosomes herein) is originated from late endosomes or multivesicular bodies (MVBs).
Takahide Matsui +3 more
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Deep and fast label-free Dynamic Organellar Mapping
Nature Communications, 2023 The Dynamic Organellar Maps (DOMs) approach combines cell fractionation and shotgun-proteomics for global profiling analysis of protein subcellular localization.
Julia P. Schessner +4 more
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A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation in Arabidopsis thaliana. [PDF]
, 2020 In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood.
Armbruster, Ute +6 more
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Editorial overview: Membrane trafficking [PDF]
Current Opinion in Cell Biology, 2019 [No Abstract]
Cullen, Peter J., Nakano, Akihiko
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