Results 11 to 20 of about 262,474 (307)

Flotillins in membrane trafficking and physiopathology. [PDF]

Biol Cell
AbstractFlotillin 1 and 2 are highly conserved and homologous members of the stomatin, prohibitin, flotillin, HflK/C (SPFH) family. These ubiquitous proteins assemble into hetero‐oligomers at the cytoplasmic membrane in sphingolipid‐enriched domains. Flotillins play crucial roles in various cellular processes, likely by concentrating sphingosine.
Bodin S, Elhabashy H, Macdonald E, Winter D, Gauthier-Rouvière C.   +4 more
europepmc   +4 more sources

Membrane trafficking in health and disease [PDF]

Disease Models & Mechanisms, 2020
ABSTRACT Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a Glance article and accompanying poster, we outline the major cellular trafficking pathways and discuss how defects in the function of the molecular machinery ...
Rebecca Yarwood, John Hellicar, Philip G. Woodman, Martin Lowe   +3 more
openaire   +5 more sources

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Molecular Neurodegeneration, 2019
Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer’s disease.
Zoë P. Van Acker, Marine Bretou, Wim Annaert   +2 more
doaj   +1 more source

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Schirmer, Eric C, Eric C. Schirmer, Ohba, Tomoyuki, Tomoyuki Ohba, Takeharu Nishimoto, Larry Gerace   +7 more
core   +1 more source

A Proteomics Approach to Membrane Trafficking [PDF]

Plant Physiology, 2008
Membrane trafficking, including that of integral membrane proteins as well as peripherally associated proteins, appears to be a vital process common to all eukaryotes. An important element of membrane trafficking is to determine the protein composition of the various endomembrane compartments ...
Groen, A.J., de Vries, S.C., Lilley, K.S.   +2 more
openaire   +3 more sources

Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c In Vitro [PDF]

, 2008
Background: Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin.
Nia J Bryant, Gould, G.W., Veronica Aran, James A McNew, Gwyn W Gould, McNew, J.A., Bryant, N.J., Aran Veronica, Avani Verma, Gould Gwyn W., Aran-Ponte, V., Fiona M Brandie, Bryant Nia J., Verma Avani, Brandie Fiona M., McNew James A., Brandie, F.M., Verma, A.   +17 more
core   +1 more source

An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook

BMC Biology, 2017
Background In a macro-molecular complex, any minor change may prove detrimental. For a supra-molecular nano-machine like the bacterial flagellum, which consists of several distinct parts with specific characteristics, stability is important.
Clive S. Barker, Irina V. Meshcheryakova, Alla S. Kostyukova, Peter L. Freddolino, Fadel A. Samatey   +4 more
doaj   +1 more source

Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition

STAR Protocols, 2020
Summary: Lysosomes are dynamic organelles that serve as regulatory hubs in cellular homeostasis. Changes in lysosome morphology, composition, and turnover are typically linked to disease.
Arun Kumar Tharkeshwar, David Demedts, Wim Annaert   +2 more
doaj   +1 more source

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
core   +1 more source

Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]

, 2012
The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core   +1 more source