Results 11 to 20 of about 398,965 (304)

The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7

Cell Reports, 2021
Summary: Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab family. Besides possible recycling routes to the plasma membrane and various organelles, previously described endocytic pathways (e.g., clathrin-mediated ...
Evgeniya Trofimenko, Yuta Homma, Mitsunori Fukuda, Christian Widmann   +3 more
doaj   +1 more source

Multiple Domains in the Kv7.3 C-Terminus Can Regulate Localization to the Axon Initial Segment

Frontiers in Cellular Neuroscience, 2020
The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing.
Louise Leth Hefting, Elisa D’Este, Emil Arvedsen, Tau Benned-Jensen, Hanne Borger Rasmussen   +4 more
doaj   +1 more source

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Molecular Neurodegeneration, 2019
Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer’s disease.
Zoë P. Van Acker, Marine Bretou, Wim Annaert   +2 more
doaj   +1 more source

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]

, 2015
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair, Bakeberg, Belzile, Bergman, Cao, Chacon-Heszele, Chih, Dentler, Dorn, Engel, Ferris, Firestone, Garcia-Gonzalo, Gerdes, Goetz, Goodenough, Goodenough, Hildebrandt, Hogan, Hu, Hunnicutt, Hunnicutt, Hyman, Kim, Kong, Kubo, Lancaster, Lin, Liu, Liu, Malicki, Meng, Milenkovic, Molla-Herman, Mukhopadhyay, Mukhopadhyay, Nachury, Ning, Ocbina, Pasquale, Pazour, Pazour, Pedersen, Pijst, Pijst, Rohatgi, Rohatgi, Rosenbaum, Sang, Shih, Snell, Snell, Snell, Tai, Wang, Wang, Wang, Weise, Wiese, Williams, Wilson, Wood, Wood, Ye   +63 more
core   +3 more sources

Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system

Open Biology, 2021
Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases.
Meng-Hsuan Wen, Xihong Xie, Pei-San Huang, Karen Yang, Tai-Yen Chen   +4 more
doaj   +1 more source

The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]

, 2016
Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E, Banna, Chris D, Low, Seng Hui, Radeke, Carolyn M, Sharma, Nikunj, Soo Hoo, Linda, Vandenberg, Carol A, Weimbs, Thomas   +7 more
core   +1 more source

Membrane Trafficking During Plant Cytokinesis [PDF]

Traffic, 2002
Plant morphogenesis is regulated by cell division and expansion. Cytokinesis, the final stage of cell division, culminates in the construction of the cell plate, a unique cytokinetic membranous organelle that is assembled across the inside of the dividing cell.
Sebastian Y, Bednarek, Tanya G, Falbel
openaire   +2 more sources

The trafficking and targeting of P2X receptors [PDF]

, 2013
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very ...
Murrell-Lagnado, Ruth D, Robinson, Lucy E   +1 more
core   +3 more sources

An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook

BMC Biology, 2017
Background In a macro-molecular complex, any minor change may prove detrimental. For a supra-molecular nano-machine like the bacterial flagellum, which consists of several distinct parts with specific characteristics, stability is important.
Clive S. Barker, Irina V. Meshcheryakova, Alla S. Kostyukova, Peter L. Freddolino, Fadel A. Samatey   +4 more
doaj   +1 more source

Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition

STAR Protocols, 2020
Summary: Lysosomes are dynamic organelles that serve as regulatory hubs in cellular homeostasis. Changes in lysosome morphology, composition, and turnover are typically linked to disease.
Arun Kumar Tharkeshwar, David Demedts, Wim Annaert   +2 more
doaj   +1 more source