Results 21 to 30 of about 262,639 (307)
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]
, 2011 Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga +28 more
core +1 more source
Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]
, 2012 The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core +1 more source
Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions
Nature Communications, 2016 The bacterial flagellar hook is made up of many copies of the protein FlgE. Here, the authors report the full structure of the hook from Campylobacter jejuni and show that its overall structure is different from that of the previously published filament.
Hideyuki Matsunami +4 more
doaj +1 more source
eLife, 2020 γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data.
Abril Angélica Escamilla-Ayala +12 more
doaj +1 more source
The road not taken: Less traveled roads from the TGN to the plasma membrane [PDF]
, 2015 : The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma
Anne Spang, Spang, Anne
core +1 more source
Studies on interactions of exported "plasmodium falciparum" membrane proteins [PDF]
, 2014 Responsible for about 700’000 annual deaths worldwide, malaria today is still one of the major health problems in developing countries. The most deadly form of human malaria called malaria tropica is caused by the apicomplexan parasite Plasmodium ...
Dietz, Olivier
core +1 more source
A new role for clathrin adaptor proteins 1 and 3 in lipoplex trafficking [PDF]
, 2014 Intracellular protein trafficking through secretory and endocytic pathways depends on the function of adaptor proteins that bind motifs on cargo proteins.
Gumbs, Jade +7 more
core +1 more source
Membrane Trafficking Inspired Hydrolysis of Non-Activated Esters at Physiological pH [PDF]
, 2020 Natural enzymes establish the proximity of the substrates to perform challenging reactions in aqueous medium, whereas most chemical catalysts typically follow stochastic way and are less efficient.
Kingshuk, Mahanty +4 more
core +1 more source
F1000Research, 2020 Melanin pigments are responsible for human skin and hair color, and they protect the body from harmful ultraviolet light. The black and brown melanin pigments are synthesized in specialized lysosome-related organelles called melanosomes in melanocytes ...
Norihiko Ohbayashi, Mitsunori Fukuda
doaj +1 more source
Biochemical and structural insights into Rab12 interactions with RILP and its family members
Scientific Reports, 2021 Alongside its biosynthetic functions, the small GTPase Rab12 negatively regulates mast cell (MC) exocytosis by its interaction with RILP to promote retrograde transport of the MC secretory granules.
Jana Omar +7 more
doaj +1 more source