Results 21 to 30 of about 262,474 (307)
Complete structure of the bacterial flagellar hook reveals extensive set of stabilizing interactions
Nature Communications, 2016 The bacterial flagellar hook is made up of many copies of the protein FlgE. Here, the authors report the full structure of the hook from Campylobacter jejuni and show that its overall structure is different from that of the previously published filament.
Hideyuki Matsunami +4 more
doaj +1 more source
eLife, 2020 γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data.
Abril Angélica Escamilla-Ayala +12 more
doaj +1 more source
The road not taken: Less traveled roads from the TGN to the plasma membrane [PDF]
, 2015 : The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma
Anne Spang, Spang, Anne
core +1 more source
Studies on interactions of exported "plasmodium falciparum" membrane proteins [PDF]
, 2014 Responsible for about 700’000 annual deaths worldwide, malaria today is still one of the major health problems in developing countries. The most deadly form of human malaria called malaria tropica is caused by the apicomplexan parasite Plasmodium ...
Dietz, Olivier
core +1 more source
A new role for clathrin adaptor proteins 1 and 3 in lipoplex trafficking [PDF]
, 2014 Intracellular protein trafficking through secretory and endocytic pathways depends on the function of adaptor proteins that bind motifs on cargo proteins.
Gumbs, Jade +7 more
core +1 more source
F1000Research, 2020 Melanin pigments are responsible for human skin and hair color, and they protect the body from harmful ultraviolet light. The black and brown melanin pigments are synthesized in specialized lysosome-related organelles called melanosomes in melanocytes ...
Norihiko Ohbayashi, Mitsunori Fukuda
doaj +1 more source
Biochemical and structural insights into Rab12 interactions with RILP and its family members
Scientific Reports, 2021 Alongside its biosynthetic functions, the small GTPase Rab12 negatively regulates mast cell (MC) exocytosis by its interaction with RILP to promote retrograde transport of the MC secretory granules.
Jana Omar +7 more
doaj +1 more source
The yeast vacuolar membrane proteome [PDF]
, 2009 Transport of solutes between the cytosol and the vacuolar lumen is of crucial importance for various functions of vacuoles, including ion homeostasis; detoxification; storage of different molecules such as amino acids, phosphate, and calcium ions; and ...
Poolman, Bert, +18 more
core +1 more source
Theory of Cargo and Membrane Trafficking [PDF]
, 2016 Endocytosis underlies many cellular functions including signaling and nutrient uptake. The endocytosed cargo gets redistributed across a dynamic network of endosomes undergoing fusion and fission. Here, a theoretical approach is reviewed which can explain how the microscopic properties of endosome interactions cause the emergent macroscopic properties ...
Foret, Lionel +2 more
openaire +2 more sources
Cells, 2022 In obesity, chronic membrane-localization of CD36 free fatty acid (FFA) translocase, but not other FFA transporters, enhances FFA uptake and intracellular lipid accumulation.
Nicole K. Nakamura +3 more
doaj +1 more source