Results 31 to 40 of about 398,965 (304)
Diacylglycerol kinases in membrane trafficking [PDF]
Cellular Logistics, 2015 Diacylglycerol kinases (DGKs) belong to a family of cytosolic kinases that regulate the phosphorylation of diacylglycerol (DAG), converting it into phosphatidic acid (PA). There are 10 known mammalian DGK isoforms, each with a different tissue distribution and substrate specificity.
Shuwei, Xie +2 more
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Frontiers in Cell and Developmental Biology, 2021 Membrane trafficking is critical for cellular homeostasis, which is mainly carried out by small GTPases, a class of proteins functioning in vesicle budding, transport, tethering and fusion processes. The accurate and organized membrane trafficking relies
Zehui Lei +5 more
doaj +1 more source
The role of traction in membrane curvature generation. [PDF]
, 2018 Curvature of biological membranes can be generated by a variety of molecular mechanisms including protein scaffolding, compositional heterogeneity, and cytoskeletal forces.
Alimohamadi, H +4 more
core +1 more source
Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3. [PDF]
PLoS ONE, 2014 The sweet taste receptors T1r2 and T1r3 are included in the T1r taste receptor family that belongs to class C of the G protein-coupled receptors. Heterodimerization of T1r2 and T1r3 is required for the perception of sweet substances, but little is known ...
Madoka Shimizu +4 more
doaj +1 more source
An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [PDF]
, 2015 Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and
Doyle, Siamsa M +10 more
core +1 more source
In Vivo Tissue-wide Synchronization of Mitochondrial Metabolic Oscillations
Cell Reports, 2014 Little is known about the spatiotemporal coordination of mitochondrial metabolism in multicellular organisms in situ. Using intravital microscopy in live animals, we report that mitochondrial metabolism undergoes rapid and periodic oscillations under ...
Natalie Porat-Shliom +5 more
doaj +1 more source
Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies
Cells, 2018 Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in eukaryotes.
Yoshihiko Kuchitsu, Mitsunori Fukuda
doaj +1 more source
SNARE proteins in membrane trafficking [PDF]
Traffic, 2017 SNAREsare the core machinery mediating membrane fusion. In this review, we provide an update on the recent progress onSNAREsregulating membrane fusion events, especially the more detailed fusion processes dissected by well‐developed biophysical methods and in vitro single molecule analysis approaches.
Tuanlao, Wang +2 more
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Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]
, 2012 Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah +4 more
core +1 more source
Controlling Cargo Trafficking in Multicomponent Membranes [PDF]
Nano Letters, 2018 Biological membranes typically contain a large number of different components dispersed in small concentrations in the main membrane phase, including proteins, sugars, and lipids of varying geometrical properties. Most of these components do not bind the cargo.
Curk, Tine +4 more
openaire +4 more sources