Results 81 to 90 of about 44,845 (236)

Can ecosystem-based adaptation address the adaptation needs of smallholder farmers? Insights from smallholder coffee and subsistence farmers in central America [PDF]

, 2015
In many regions, climate change is having significant adverse impacts on the agricultural production and livelihoods of smallholder farmers, with important consequences for global food security..
Alpizar, Francisco, Avelino, Jacques, Bautista Solis, Pavel, Cardenas, Jose Mario, Donatti, Camila I., Martinez-Rodriguez, Ruth, Rapidel, Bruno, Saborio-Rodriguez, Milagro, Vignola, Raffaele, Viguera, Barbara   +9 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Golgi clustering by the deficiency of COPI-SNARE in Drosophila photoreceptors

Frontiers in Cell and Developmental Biology
A comprehensive study of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) in the fly genome by RNAi in Drosophila photoreceptors indicated that knockdown of any of the COPI-SNAREs, Syx18, Sec20, and Use1, resulted in the ...
Tatsuya Tago, Yumi Yamada, Yumi Goto, Kiminori Toyooka, Yuka Ochi, Takunori Satoh, Akiko K. Satoh   +6 more
doaj   +1 more source

Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]

, 2017
The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R., Larson, Emily R., Marion-Poll, Annie, Roux, Camille, Van Zelm, Eva   +4 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Best management practices in counting urban black bears

Human-Wildlife Interactions, 2017
DNA-based capture-mark-recapture (CMR) techniques are commonly used to obtain population parameters of black bears (Ursus americanus) in rural and wildland landscapes; however, these techniques have not been implemented in urban clusters (i.e., 2,500 to ...
Jonathan L. Fusaro, Mary M. Conner, Michael R. Conover, Timothy J. Taylor, Marc W. Kenyon Jr.   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Use of Snares to Live-Capture Beavers

Human-Wildlife Interactions, 2017
Wildlife managers, researchers, and nuisance-control operators often require a nonlethal means of capturing beavers (Castor canadensis). Historically, live-capture has relied on enclosure-type traps such as Bailey or Hancock traps.
Lance B. McNew Jr., Clayton K. Nielsen, Craig K. Bloomquist   +2 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Syntaxin 16 is a master recruitment factor for cytokinesis [PDF]

, 2013
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and ...
Alexandra Kaupisch, Barr FA, Bastos RN, Bissig C, Blum R, Carlton J, Carlton JG, Carr CM, Chen X.-W., Chesneau L, Choudhury A, Dambournet D, Dulubova I, Elia N, Fededa JP, Fielding AB, Fielding AB, Francis A. Barr, Glotzer M, Goss JW, Gromley A, Guizetti J, Gwyn W. Gould, Hong W, Hélia Neto, Jung JJ, Lee HH, Louise L. Collins, Low SH, Manickam V, Mondal G, Munson M, Neto H, Prekeris R, Proctor KM, Rannou Y, Riggs KA, Scales SJ, Schiel JA, Schiel JA, Schiel JA, Schiel JA, Simon GC, Simonsen A, Struthers MS, Tellam JT, TerBush DR, Xu H, Zhang XM   +48 more
core   +2 more sources