Results 71 to 80 of about 15,533,264 (179)

No Effect of Preoperative Mepolizumab on Early Postoperative Healing After ESS for Severe CRSwNP

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 6, December 2026.
ABSTRACT Objective To evaluate postoperative endoscopic mucosal healing 2 weeks after ESS in patients with severe CRSwNP treated with surgery alone versus surgery combined with biologics initiated 2 weeks preoperatively. Methods In this exploratory post hoc analysis, patients with severe CRSwNP were divided into two cohorts: ESS alone and ESS with ...
A. S. Homøe   +7 more
wiley   +1 more source

Clinical Effects of Adjunctive Shoseiryuto Therapy in Refractory Eosinophilic Chronic Rhinosinusitis: A Pilot Retrospective Case Series Focusing on Mucus‐Related Symptoms

open access: yesTraditional &Kampo Medicine, Volume 13, Issue 3, December 2026.
ABSTRACT Aim To evaluate the efficacy and safety of adjunctive shoseiryuto, a traditional Japanese Kampo medicine, in patients with refractory eosinophilic chronic rhinosinusitis (ECRS), with particular attention to mucus‐related symptoms. Methods This retrospective pilot case series was conducted at Osaka Medical and Pharmaceutical University Hospital
Yusuke Kikuoka
wiley   +1 more source

Complications and Clinical Outcomes Following Modified Endoscopic Denker's With Pyriform Aperture Preservation: A Prospective Analysis

open access: yesInternational Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1260-1268, November 2026.
ABSTRACT Background The modified endoscopic Denker's (MED) approach provides access to all maxillary sinus (MS) walls for resection of various MS and retromaxillary pathologies, but the anteromedial maxilla has historically been resected. This study determined complication rates and outcomes following MED with pyriform aperture (PA) preservation ...
Yasser Almansour   +5 more
wiley   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

open access: yesInternational Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1309-1317, November 2026.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu   +9 more
wiley   +1 more source

Inflammatory Signatures Beyond Th1/Th2 Endotypes Provide Insights Into Postoperative Recurrence in Chronic Rhinosinusitis

open access: yesInternational Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1269-1279, November 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel   +9 more
wiley   +1 more source

Cognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review

open access: yesInternational Forum of Allergy &Rhinology, Volume 16, Issue 11, Page 1330-1341, November 2026.
ABSTRACT Background Cognitive dysfunction is increasingly recognized as an extra‐nasal manifestation of chronic rhinosinusitis (CRS). This scoping review characterizes the primary evidence on cognition in adult CRS, covering measures, treatment response, and incident dementia.
Luke M. O'Neil   +5 more
wiley   +1 more source

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