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Functional Analysis of SNPs Variants of BCRP/ABCG2
Pharmaceutical Research, 2004The aim of the current study was to identify the effect of single nucleotide polymorphisms (SNPs) in breast cancer resistance protein (BCRP/ABCG2) on its localization, expression level, and transport activity.The cellular localization was identified using the wild type and seven different SNP variants of BCRP (V12M, Q141K, A149P, R163K, Q166E, P269S ...
Chihiro, Kondo +9 more
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2010
SNP association studies investigate the relationship between complex diseases and one’s genetic predisposition through Single Nucleotide Poly- morphisms. The studies provide the analyst with a wealth of data and lots of challenges as the moderate to small risk changes are hard to detect and, moreover, the interest focusses not on the identification of ...
Tina Müller +5 more
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SNP association studies investigate the relationship between complex diseases and one’s genetic predisposition through Single Nucleotide Poly- morphisms. The studies provide the analyst with a wealth of data and lots of challenges as the moderate to small risk changes are hard to detect and, moreover, the interest focusses not on the identification of ...
Tina Müller +5 more
openaire +1 more source
Meta-Analysis of SNP-Environment Interaction with Heterogeneity
Human Heredity, 2019Meta-analyses are widely used in genome-wide association studies to combine the results obtained from multiple studies. Classical random-effects methods treat genetic heterogeneity as a random effect and consider it as a portion of the variance associated with a fixed effect of the variant.
Qinqin, Jin, Gang, Shi
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Construction and analysis of genome-wide SNP networks
2012 IEEE 6th International Conference on Systems Biology (ISB), 2012The study of gene regulatory network (GRN) and protein protein interaction network (PPI) is believed to be fundamental to the understanding of molecular processes and functions in system biology and therefore, attracted more and more attentions in past few years.
Yang Liu 0100 +4 more
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Multi-SNP Haplotype Analysis Methods for Association Analysis
2017Haplotype analysis forms the basis of much of genetic association analysis using both related and unrelated individuals (we concentrate on unrelated). For example, haplotype analysis indirectly underlies the SNP imputation methods that are used for testing trait associations with known but unmeasured variants and for performing collaborative post-GWAS ...
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Haploview: Visualization and Analysis of SNP Genotype Data
Cold Spring Harbor Protocols, 2009INTRODUCTIONAssociation studies involve accessing, parsing, generating, and analyzing large volumes of data, often carried out in many steps over many months. Large-scale surveys of genetic variation, such as the International HapMap Project, and rapidly increasing volumes of single-nucleotide polymorphism (SNP) genotyping data have created exciting ...
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Gas-sensing mechanism of Cr doped SnP monolayer to SF partial discharge decomposition components
Applied Surface Science, 2021Qu Zhou, Wen Zeng, Jingxuan Wang
exaly