Results 211 to 220 of about 83,042 (297)

Neuregulin 4‐dependent MAPK amplification mediates urate‐induced β‐cell dysfunction

Journal of Diabetes Investigation, EarlyView.
Hyperuricemia impairs glucose homeostasis by inducing pancreatic β‐cell apoptosis without insulin resistance. In male Uox‐KO mice, urate upregulates Nrg4, which amplifies MAPK signaling and drives β‐cell death. Thus, hyperuricemia disrupts glucose metabolism via the Nrg4‐MAPK axis.
Yunyang Wang, Kun Zhang, Zhiyuan Li, Shuhui Hu, Yiru Zhang, Yulei Zhao, Xiaohan Liu, Jie Lu   +7 more
wiley   +1 more source

Genome-wide QTL mapping for stripe rust resistance in spring wheat line PI 660122 using the Wheat 15K SNP array. [PDF]

Front Plant Sci, 2023
Yan Q, Jia G, Tan W, Tian R, Zheng X, Feng J, Luo X, Si B, Li X, Huang K, Wang M, Chen X, Ren Y, Yang S, Zhou X.   +14 more
europepmc   +1 more source

Proteomic analysis in hidradenitis suppurativa reveals systemic inflammation in all disease stages

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Proteomic profiling reveals systemic inflammation in patients with hidradenitis suppurativa, even in early disease. Distinct mediators (e.g. TGF‐α, OSM, HGF) are elevated early, whereas others correlate with clinical severity (e.g. IL‐6, VEGF‐A, IL‐17A) or disease duration (e.g.
Lotta Sandelin Francke, Ansam Al‐Bayatti, Hanqian Zhang, Mohammad Alimohammadi, Hans Törmä, Enikö Sonkoly   +5 more
wiley   +1 more source

Comparison between SNP array and imputed data to estimate population structure and ROH hotspots in horse breeds. [PDF]

BMC Genomics
Chessari G, Reich P, Criscione A, Falker-Gieske C, Mastrangelo S, Tumino S, Bordonaro S, Marletta D, Tetens J.   +8 more
europepmc   +1 more source

Genes, fish and fisheries: translating science into policy

Journal of Fish Biology, EarlyView.
Abstract The 2024 Annual Symposium of the Fisheries Society of the British Isles reviewed the burgeoning impact of ‘omics’ technologies on fish ecology, management and forecasting. As with life sciences more generally, major advances in speed, cost‐effectiveness and breadth of applications in ‘omics’ has had profound societal and environmental impacts.
Gary R. Carvalho
wiley   +1 more source

First development of a 100 K SNP array for small yellow croaker and its application in genomic selection for growth and disease resistance. [PDF]

BMC Genomics
Liu F, Wang R, Ye T, Zhu J, Guo D, Zhan W, Lou B.   +6 more
europepmc   +1 more source

Exploring chromosomal variations in garden roses: Insights from high-density SNP array data and a new tool, Qploidy. [PDF]

Plant Genome
Taniguti CH, Lau J, Hochhaus T, Arias DCL, Hokanson SC, Zlesak DC, Byrne DH, Klein PE, Riera-Lizarazu O.   +8 more
europepmc   +1 more source

Reconfiguring biofortification strategies to transform food systems and address micronutrient deficiency of the 21st century

Journal of Integrative Plant Biology, EarlyView.
This review explores how to make staple foods and horticultural crops more nutritious, including how artificial intelligence‐based screening of gene banks helps deploy nutritionally rich germplasm into breeding. Genome editing can help develop crops richer in minerals, vitamins, and health‐promoting compounds, supporting healthier diets and more ...
Rhowell Jr. N. Tiozon, Alisdair R. Fernie, Nese Sreenivasulu   +2 more
wiley   +1 more source

Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants. [PDF]

Fam Cancer
Ala-Kulju K, Carpén O, Lappalainen M, Pehrsson M.   +3 more
europepmc   +1 more source

Sugarcane breeding array 1.0: A high‐density SNP chip for genomic studies and molecular breeding

Journal of Integrative Plant Biology, EarlyView.
Sugarcane Breeding Array 1.0, a high‐density single‐nucleotide polymorphism array, is based on deep whole‐genome resequencing of diverse sugarcane accessions. Validation demonstrated its robust performance and cost‐effectiveness in population structure analysis, genome‐wide association studies, and molecular breeding applications.
Meiyan Chen, Chaohua Xu, Ni Wei, Bowen Kuang, Peng Liu, Jinkang Song, Bo Yu, Fengzhen Wu, Xin Lu, Xiping Yang   +9 more
wiley   +1 more source