Results 81 to 90 of about 1,520,842 (344)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Large SNP arrays for genotyping in crop plants

Journal of Biosciences, 2012
Genotyping with large numbers of molecular markers is now an indispensable tool within plant genetics and breeding. Especially through the identification of large numbers of single nucleotide polymorphism (SNP) markers using the novel high-throughput sequencing technologies, it is now possible to reliably identify many thousands of SNPs at many ...
Gregor Durstewitz, Andreas Polley, Joerg Plieske, Hartmut Luerssen, Martin W. Ganal, Eva-Maria Graner, Ralf Wieseke   +6 more
openaire   +3 more sources

Development and Validation of 58K SNP-Array and High-Density Linkage Map in Nile Tilapia (O. niloticus)

bioRxiv, 2018
Despite being the second most important aquaculture species in the world accounting for 7.4% of global production in 2015, tilapia aquaculture has lacked genomic tools like SNP-arrays and high-density linkage maps to improve selection accuracy and ...
R. Joshi, M. Árnyasi, S. Lien, H. M. Gjøen, A. Alvarez, M. Kent   +5 more
semanticscholar   +1 more source

Identification of structural aberrations in cancer by SNP array analysis [PDF]

Genome Biology, 2007
Recent studies using single-nucleotide polymorphism arrays have pinpointed novel oncogenes and tumor suppressors involved in specific types of human cancers.
A. Thomas Look, Stefan Heinrichs
openaire   +3 more sources

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

SNP Array as a Tool for Prenatal Diagnosis of Congenital Heart Disease Screened by Echocardiography: Implications for Precision Assessment of Fetal Prognosis

Risk Management and Healthcare Policy, 2021
Hailong Huang,1,2,* Meiying Cai,1,2,* Yan Wang,1,2 Bin Liang,1,2 Na Lin,1,2 Liangpu Xu1,2 1Center for Prenatal Diagnosis, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, People&
Huang H, Cai M, Wang Y, Liang B, Lin N, Xu L   +5 more
doaj  

Rice3K56 is a high-quality SNP array for genome-based genetic studies and breeding in rice (Oryza sativa L.)

Crop Journal, 2023
Single nucleotide polymorphism (SNP) genotyping arrays provide an optimal high-throughput platform for genetic research and molecular breeding programs in both animals and plants.
Chaopu Zhang, Min Li, Lunping Liang, Jun Xiang, Fan Zhang, Chenyang Zhang, Yizhen Li, Jing Liang, Tianqing Zheng, Fanlin Zhang, Hua Li, Binying Fu, Yingyao Shi, Jianlong Xu, Bingchuan Tian, Zhikang Li, Wensheng Wang   +16 more
doaj   +1 more source

Development of a maize 55 K SNP array with improved genome coverage for molecular breeding

Molecular breeding, 2017
With the decrease of cost in genotyping, single nucleotide polymorphisms (SNPs) have gained wide acceptance because of their abundance, even distribution throughout the maize (Zea mays L.) genome, and suitability for high-throughput analysis.
Cheng Xu, Yonghong Ren, Yinqiao Jian, Zifeng Guo, Yan Zhang, Chuanxiao Xie, Junjie Fu, Hongwu Wang, Guoying Wang, Yunbi Xu, Ping Li, C. Zou   +11 more
semanticscholar   +1 more source

Arrayed Primer Extension in the “Array of Arrays” Format: A Rational Approach for Microarray-Based SNP Genotyping [PDF]

Genetic Testing, 2007
This study provides a new version of the arrayed primer extension (APEX) protocol adapted to the 'array of arrays' platform using an instrumental setup for microarray processing not previously described. The primary aim of the study is to implement a system for rational cost-efficient genotyping where multiple singlenucleotide polymorphisms (SNPs) and ...
Klito, N, Tan, Q, Nyegaard, M, Brusgaard, K, Thomassen, M, Skouboe, C, Dahlgaard, Jesper, Kruse, TA   +7 more
openaire   +5 more sources

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source