Results 151 to 160 of about 337,686 (261)
Cost effective SNP genotyping assays for castor
, 2016 A cost-effective SNP genotyping assay based on ‘Kompetitive Allele Specific PCR genotyping system (KASP), a fluorescent endpoint genotyping technology of LGC Genomics was developed for 300 SNP loci in castor.
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Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, EarlyView.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
Genotyping-by-Sequencing: efficiency and reproducibility checks
, 2015 Genotyping-by-Sequencing (GBS) has the potential to be a cost effective, reproducible and high-throughput SNP genotyping method. We have been investigating GBS in a number of livestock species, with an emphasis on Sheep.
Rudiger Brauning (47247) +4 more
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Clinical Pharmacology &Therapeutics, EarlyView.Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz +5 more
wiley +1 more source
Genotyping-by-Sequencing - Development in livestock
, 2015 Recent advances in next generation sequencing technology have increased the output/cost to a level that where genotyping-by-sequencing (GBS) in livestock and plant crops as well as aquaculture species can be considered. GBS has the potential to be a cost
Rudiger Brauning (47247) +4 more
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Clinical Pharmacology &Therapeutics, EarlyView.The NAT2 pharmacogene is essential in drug metabolism, particularly for aromatic amines and hydrazines. Genetic variations in NAT2 categorize individuals as rapid, intermediate, or poor metabolizers based on their acetylation capacity to inform dosing guidelines.
Shobana John +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Low‐dose aspirin is no longer routinely recommended for the primary prevention of cardiovascular disease in older adults due to a lack of net benefit over bleeding risk. We hypothesized that genetic subgroups may experience differential harm or benefit from aspirin therapy.
Peter D. Fransquet +8 more
wiley +1 more source
Фактори експериментальної еволюції організмів, 2014 Aims. The determination of the contribution of precursor populations into the genetic structure of modern inbreds accoding to the results of DNA single nucleotide polymorphism analysis. Methods.
В. Ю. Черчель +5 more
doaj
Clinical Pharmacology &Therapeutics, EarlyView.Abemaciclib increases serum creatinine by inhibiting renal tubular transporters rather than reducing true glomerular filtration rate, a phenomenon known as pseudo‐acute kidney injury. Creatinine–cystatin C discrepancy and genetic determinants of this elevation remain insufficiently characterized in Japanese patients.
Hiroaki Watanabe +5 more
wiley +1 more source
Zebrafish inversin mutants develop scoliosis in the absence of laterality defects
Developmental Dynamics, EarlyView.Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick +3 more
wiley +1 more source