Results 161 to 170 of about 129,104 (260)

Development and Analytical Validation of a Laboratory‐Customized TaqMan‐MGB Probe Method for CYP2C19 Genotyping

Journal of Clinical Laboratory Analysis, EarlyView.
A laboratory‐customized, open‐sequence TaqMan‐MGB probe assay was developed for detecting CYP2C19*2 and CYP2C19*17 polymorphisms using dried blood spot‐derived DNA. The assay demonstrated allele‐specific discrimination, candidate LODs of 1.17 × 102 copies/μL for CYP2C19*2 and 0.94 × 103 copies/μL for CYP2C19*17, and repeatability with CVs below 10%. In
Yaqun Liu, Lianghui Chen, Xuanyi Zheng, Peikui Yang, Yicun Chen, Chengsong Xie, Zhenxia Zhang, Yuzhong Zheng   +7 more
wiley   +1 more source

Development of a next generation SNP genotyping array for wheat. [PDF]

Plant Biotechnol J
Burridge AJ, Winfield M, Przewieslik-Allen A, Edwards KJ, Siddique I, Barral-Arca R, Griffiths S, Cheng S, Huang Z, Feng C, Dreisigacker S, Bentley AR, Brown-Guedira G, Barker GL.   +13 more
europepmc   +1 more source

Application of Cell‐Free DNA Barcode‐Enabled Single‐Molecule Test for Non‐Invasive Prenatal Testing of α‐Thalassemia and β‐Thalassemia

Journal of Clinical Laboratory Analysis, EarlyView.
We evaluated the cfBEST assay for non‐invasive prenatal testing of α‐ and β‐thalassemia in 72 families. The assay correctly identified 88 of 93 fetal alleles, achieving an overall accuracy of 94.6%, a sensitivity of 94%, and a specificity of 95.35%, with 100% concordance with postnatal follow‐up.
Qin Liu, Na Ma, Wanglan Tang, Qianting Chen, Deguo Tang, Chunyan Zeng, Xiaofeng Wang, Hui Xi   +7 more
wiley   +1 more source

Correction to: Evidence for extensive hybridization and past introgression events in feather grasses using genome-wide SNP genotyping. [PDF]

BMC Plant Biol, 2022
Baiakhmetov E, Ryzhakova D, Gudkova PD, Nobis M.   +3 more
europepmc   +1 more source

Young adult self‐harm: The role of victimisation and polygenic risk in a population‐based longitudinal study

JCPP Advances, EarlyView.
Abstract Background Victimisation has been associated with self‐harm (with or without suicidal intent), but little is known about this association during young adulthood—a distinct developmental period. Further, not all individuals who experience victimisation will later engage in self‐harm, suggesting the influence of other factors.
Filip Marzecki, Isabelle Ouellet‐Morin, Helena M. S. Zavos, Sylvana Côté, Richard E. Tremblay, Jean‐Philippe Gouin, Massimiliano Orri, Michel Boivin, Marie‐Claude Geoffroy   +8 more
wiley   +1 more source

Investigating the impact of early adversity on perceived support from parents and friends in preadolescence: Do genetic predispositions and timing of exposure matter?

JCPP Advances, EarlyView.
This study found that youth with a higher genetic risk for internalizing and externalizing problems were more likely to face adversity within their home, highlighting the need for risk mitigation. These associations varied by adversity type and timing. Additionally, low family income, parental divorce, and externalizing behaviours were linked to lower ...
Christina Y. Cantave, Marthe de Roo, Charlotte Vrijen, Tina Kretschmer   +3 more
wiley   +1 more source

Feasibility of SNP Genotyping Using Dried Blood Spot Samples Collected in an Epidemiological Study and Its Integration With Genetic Risk Analysis for Endometriosis. [PDF]

Reprod Med Biol
Kitahara Y, Ideno Y, Tomiyoshi K, Onizuka Y, Nagai K, Iwase A, Shimada J, Ohnishi H, Hayashi K.   +8 more
europepmc   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Preimplantation genetic testing for structural rearrangements by genome-wide SNP genotyping and haplotype analysis: a prospective multicenter clinical study. [PDF]

EBioMedicine
Zhang S, Gao Y, Wang X, Li Q, Tan J, Liang B, Gao M, Wu J, Ling X, Liu J, Teng X, Li H, Sun Y, Huang W, Tong X, Lei C, Li H, Wang J, Li S, Xu X, Zhang J, Wu W, Liang S, Ou J, Zhao Q, Jin R, Zhang Y, Xu C, Lu D, Yan J, Sun X, Choy KW, Xu C, Chen ZJ.   +33 more
europepmc   +1 more source

Shared genetics between ADHD and reading/language abilities: Genome‐wide correlations, stratified enrichment, cross‐trait association, and mendelian randomization

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) and language/reading difficulties frequently co‐occur. The extent of shared genetic architecture remains incompletely defined. We investigated genome‐wide overlap between ADHD and four core skills: word reading, nonword reading, spelling, and phoneme awareness.
Jinzhu Zhao, Shi Huang, Wei Liu, Feng Wang, Hong Qian, Xiaolin Hu   +5 more
wiley   +1 more source