Results 61 to 70 of about 219,632 (346)

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]

, 2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.
A Dehghan, Aaron Isaacs, Abbas Dehghan, AD Johnson, AD Johnson, Afshin Parsa, Alan R Shuldiner, Albert Hofman, Albert V Smith, AM Bennet, Andre Uitterlinden, Andreas Ziegler, Angelo Scuteri, Anne B Newman, Arne Schillert, Ben Oostra, BM Psaty, Bolli Thorsson, Braxton D Mitchell, Bruce M Psaty, C Meisinger, C Sabatti, Caroline Hayward, Caroline S Fox, Charles C White, Christa Meisinger, Christie Ballantyne, Christopher J O'Donnell, Cornelia van Duijn, CS Fox, D Lloyd-Jones, D Wang, Daniel H O'Leary, David J Couper, DI Chasman, DI Chasman, E Falk, EB Mathiesen, Edward G Lakatta, Eran Halperin, Eric Boerwinkle, Eva-Maria Stoegerer, Fernando Rivadeneira, Florian Ernst, Georg Homuth, Gerardo Heiss, Gianluca Usala, Gonçalo R Abecasis, Gudny Eiriksdottir, H Erich Wichmann, H Schunkert, H Yasuda, Helena Schmidt, Henry Völzke, Hugh S Markus, Jacqueline Witteman, James F Wilson, Jan Lüdemann, Jennifer E Huffman, Jens Baumert, Jerome I Rotter, JH Stein, Joachim Thiery, Jochen Seissler, Jorma Viikari, Joseph F Polak, Joshua C Bis, K Stark, K Yuan, Kari North, Katja E Petrovic, Kenneth Rice, Kent Taylor, L Adrienne Cupples, L Paternoster, Leena Peltonen, Lenore J Launer, M Kolz, M Oguri, Manuela Uda, Marco Orru, Marcus Dörr, Maryam Kavousi, Matthias Sitzer, Mika Kähönen, Muredach P Reilly, MW Lorenz, N Soranzo, Nora Franceschini, Norman Klopp, Olli Raitakari, P Greenland, Philip A Wolf, Philipp S Wild, R Nakov, R Ross, Ralph B D'Agostino, Ravi Kumar Chilukoti, Reinhold Schmidt, Renate B Schnabel, S Kathiresan, S Kathiresan, Sekar Kathiresan, Serena Sanna, Serkalem Demissie, SH Johnsen, Stefan Blankenberg, Steve Bevan, Susan R Heckbert, T Rahman, TA Manolio, Tamara B Harris, Tanja Zeller, Terho Lehtimäki, Thomas Illig, Thomas Münzel, Thor Aspelund, Ulf Schminke, V Nambi, Vijay Nambi, Vilmundur Gudnason, W Insull Jr., Wendy S Post, Wolfgang Koenig, Wolfgang Rathmann, Xia Li, XZ Zhou, YS Aulchenko, Yu-Ching Cheng   +128 more
core   +2 more sources

Whole genome SNP genotype piecemeal imputation [PDF]

BMC Bioinformatics, 2015
Background Despite ongoing reductions in the cost of sequencing technologies, whole genome SNP genotype imputation is often used as an alternative for obtaining abundant SNP genotypes for genome wide association studies. Several existing genotype imputation methods can be efficient for this purpose, while achieving various levels of imputation accuracy.
Stothard, Paul, Wang, Yining, Lin, Guohui, Wylie, Tim   +3 more
openaire   +3 more sources

Novel Design of Imputation-Enabled SNP Arrays for Breeding and Research Applications Supporting Multi-Species Hybridization

Frontiers in Plant Science, 2021
Array-based single nucleotide polymorphism (SNP) genotyping platforms have low genotype error and missing data rates compared to genotyping-by-sequencing technologies.
Gabriel Keeble-Gagnère, Raj Pasam, Kerrie L. Forrest, Debbie Wong, Hannah Robinson, Jayfred Godoy, Allan Rattey, David Moody, Daniel Mullan, Tresslyn Walmsley, Hans D. Daetwyler, Hans D. Daetwyler, Josquin Tibbits, Matthew J. Hayden, Matthew J. Hayden   +14 more
doaj   +1 more source

Large scale single nucleotide polymorphism discovery in unsequenced genomes using second generation high throughput sequencing technology: applied to turkey [PDF]

, 2009
Background - The development of second generation sequencing methods has enabled large scale DNA variation studies at moderate cost. For the high throughput discovery of single nucleotide polymorphisms (SNPs) in species lacking a sequenced reference ...
Kerstens, H.H.D., Crooijmans, R.P.M.A., Veenendaal, A., Dibbits, B.W., Chin-A-Woeng, T.F.C., Dunnen, J.T., den, Groenen, M.A.M.   +6 more
core   +2 more sources

Development and Applications of a High Throughput Genotyping Tool for Polyploid Crops: Single Nucleotide Polymorphism (SNP) Array

Frontiers in Plant Science, 2018
Polypoid species play significant roles in agriculture and food production. Many crop species are polyploid, such as potato, wheat, strawberry, and sugarcane.
Qian You, Qian You, Xiping Yang, Ze Peng, Liping Xu, Jianping Wang, Jianping Wang, Jianping Wang   +7 more
doaj   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]

, 2007
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Crameri, Andreas, Marfurt, Jutta, Mugittu, Kefas, Maire, Nicolas, Regös, Attila, Coppee, Jean Yves, Sismeiro, Odile, Burki, Richard, Huber, Eric, Laubscher, Daniel, Puijalon, Odile, Genton, Blaise, Felger, Ingrid, Beck, Hans-Peter   +13 more
core   +1 more source

Genotyping SNPs v1

, 2017
1) DNA was extracted from blood samples at DNA Chip Research Inc. 2) SNP genotyping: using the DigiTag2 assay.
Yoko Kubo, Takahiro Imaizumi, Masahiro Nakatochi, Yoshinari Yasuda, Hiroyuki Honda, Yachiyo Kuwatsuka, Sawako Kato, Kyoko Kikuchi, Takaaki Kondo, Masamitsu Iwata, Toru Nakashima, Hiroshi Yasui, Hideki Takamatsu, Hiroshi Okajima, Yasuko Yoshida, Shoichi Maruyama   +15 more
openaire   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA‐associated PF in an independent cohort of patients with early RA.
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source