Results 181 to 190 of about 526,264 (266)

SNP [PDF]

, 2018
openaire   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Dual-functional nanovesicles simultaneously inhibit stromal fibrosis and angiogenesis to suppress cholangiocarcinoma progression. [PDF]

J Nanobiotechnology
Zhang L, Duan X, Shi Q, Yao X, Chen Q, Wan J, Wang F, Ni C, Li Y, Wang M, Sheng Y, Zheng W, Liu J, Ji T, Qin Z.   +14 more
europepmc   +1 more source

Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells

British Journal of Clinical Pharmacology, EarlyView.
Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann, Julian Peter Müller, Stefan Düsterhöft, Sabrina Yamoune, Katja Susanne Just, Julia Carolin Stingl   +5 more
wiley   +1 more source

Genome-Wide Association Study of Body Mass Index in a Commercial Landrace × Yorkshire Crossbred Pig Population. [PDF]

Vet Sci
Jin L, Bai C, Chen J, Feng C, Dong F, Zhang X, Fei J, He Y, Liu W, Chen C, Sun B, Wang D, Sun H.   +12 more
europepmc   +1 more source

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 [PDF]

, 2018
Rubin, Joshua B.
core   +1 more source

Defect‐engineered iron single‐site catalysts with tailored atomic coordination for enhanced mild photothermal therapy via triad modulation of apoptosis and ferroptosis

BMEMat, EarlyView.
A defect‐engineered triad catalyst (DMOF‐SNP‐siRNA) has been developed to enhance mild photothermal therapy for cancer treatment by addressing the limitations of heat shock protein overexpression and suboptimal therapeutic outcomes. This synergy induces potent apoptotic and ferroptotic responses, significantly enhancing the photothermal and catalytic ...
Fanghua Zhang, Wendong Liu, Zhe Hao, Haijun Lu, Jinzheng Liu, Huajie Pang, Ruizhong Zhang, Xiyan Li, Zongjie Wang, Libing Zhang   +9 more
wiley   +1 more source

Genomic structural equation modeling reveals shared genetic structure of cardiac function and structure-function association studies of CLCNKA mutations. [PDF]

Sci Rep
Li X, Qin Y.
europepmc   +1 more source

Snapping Up SNPs [PDF]

BioTechniques, 1999
openaire   +3 more sources

Evaluation of gene editing in CHO cells using the Cas‐CLOVER system

Biotechnology Progress, EarlyView.
Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah, Efecan Aral, Michael Hoffman, Jennifer Tedstone, Thomas King, Jason Vitko, Maria João Sebastião, Jose M. Escandell, Mafalda M. Dias, Iona McCall, Daniel Machado, Victor Cairns, Christine DeMaria, John J. Scarcelli   +13 more
wiley   +1 more source