Results 111 to 120 of about 17,594,423 (307)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Socio-Economic Factors of Formation of Conflict Potential in the Society

open access: yesЭкономика и управление, 2019
The presented study examines the importance of the factors that affect the formation of conflict potential in the society. Aim. The study aims to determine the effect of the quality of the social and labor environment and income distribution policy on ...
Guzel’ F. Biglova   +2 more
doaj  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Social Decision-Making under Scientific Controversy, Expertise, and the Precautionary Principle [PDF]

open access: yes
Integrating scientific inputs into the regulatory process is generally attributed to experts. But, environmental issues are often characterised by an all-pervasive uncertainty and scientific and social controversies which make the experts' task difficult.
Olivier Godard
core  

Phenotypical characteristics of severe hypertriglyceridemia

open access: yesКардиоваскулярная терапия и профилактика, 2007
Aim. To study clinical course and severe complication development in patients with severe hypertriglyceridemia (HTG), >10 mmol/l. Material and methods.
T. V. Chepetova   +4 more
doaj  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Geography of Scientific Knowledge: A Proximity Approach [PDF]

open access: yes
The geography of scientific knowledge is defined as the replication process of locally produced knowledge claims. Proximity in social, cognitive, and physical dimensions promotes the sharing of tacit knowledge.
Koen Frenken
core  

Los Angeles County Social Survey, 1996 (LACSS)

open access: yes, 1996
The Los Angeles County Social Survey (LACSS) continues the Los Angeles Metropolitan Area Studies (LAMAS) and the Southern California Social Surveys (SCSS).
University of California, Los Angeles. Institute for Social Science Research.
core   +1 more source

Spleen Siliconoma

open access: yesMediterranean Journal of Hematology and Infectious Diseases, 2014
Along with a silicone lymphadenitis in axillary lymph nodes there are few observations of siliconomas with other localization in the literature. We observed female patient of 34 years that had tumor mass in the spleen after 12 years from augmentation ...
Elena Alexandrovna Semenova   +7 more
doaj  

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