Results 91 to 100 of about 12,028,240 (312)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Geography of Scientific Knowledge: A Proximity Approach [PDF]

The geography of scientific knowledge is defined as the replication process of locally produced knowledge claims. Proximity in social, cognitive, and physical dimensions promotes the sharing of tacit knowledge.
Koen Frenken
core  

RReshaping eldercare towards new professions

, 2014
The impacts of global longevity are commonly regarded as a threat to future social policy systems and structure of future welfare organizations. Focusing future needs of older adults social gerontologists have long since recognized the importance of ...
Magnusson, Finnur, Magnusson, Finnur,
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Competitiveness through knowledge – assessment of the European Union member states based on the knowledge assessment methodology (KAM) developed by the World Bank

Annals of Spiru Haret University Economic Series, 2010
The present study attempts to make a diagnosis of the progress of European Union member states in the transition towards the knowledge economy. We used the World Bank KAM Methodology developed in the programme Knowledge for Development and the database ...
Silvia-Florina COJANU, Cristina STROE, Eva MILITARU   +2 more
doaj  

Stratification and Inequality in the Secondary Education System in Romania

Systems
Education is a complex system with implications for educational policy and management. Education systems that are more comprehensive generate more equal outcomes, fostering access to opportunities for all children.
Ana-Maria Zamfir, Anamaria Beatrice Aldea, Raluca-Mihaela Molea   +2 more
doaj   +1 more source

Scientific Social Objects: The Social Objects and Multidimensional Network of the myExperiment Website

Scientific research is increasingly conducted digitally and online, and consequently we are seeing the emergence of new digital objects shared as part of the conduct and discourse of science.
De Roure, David, Newman, David, Goble, Carole, Bechhofer, Sean   +3 more
core  

Preventive interventions in socio-pedagogical social work

, 2017
Artikel behandlar socialpedagogiska angreppssätt för preventiva sociala insatser inom socialt arbeteGlobal economic, cultural and ideological process in society affect social work and the Welfare regimes in developed countries.
Dychawy Rosner, Irena, Irena, Dychawy Rosner,   +1 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source