Results 131 to 140 of about 798,697 (287)

Role-play and the discussion of the controversial issues during teacher training: teaching practices in favor of a Sustainable Development? [PDF]

, 2017
In a society that is constantly changing and deeply marked by advances in science and technology, it is essential to invest in a training that values personal and social development, as well as the understanding of the interaction Science-Technology ...
Linhares, Elisabete, Reis, Pedro
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Exploring barriers and facilitators to addressing hazardous alcohol use and AUD in mental health services: a qualitative study among Dutch professionals

Addiction Science & Clinical Practice
Background Hazardous alcohol use and alcohol use disorder (AUD) are highly prevalent among clients in mental health services, yet significant gaps remain in the adequate assessment of alcohol use and provision of appropriate alcohol interventions.
Nathalie Kools, Andrea D. Rozema, Fieke A. E. van den Bulck, Rob H. L. M. Bovens, Jolanda J. P. Mathijssen, Dike van de Mheen   +5 more
doaj   +1 more source

Early Childhood Education and Care Services, and Parents’ Work–Life Balance

Education Sciences
Parents’ work–life balance represents a major challenge, especially for those who have young children. The present article aims to identify the perceptions of parents relating to the purpose of early childhood education and care (ECEC) services, care ...
Aniela Matei, Mihaela Ghența, Luise Mladen-Macovei   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Flexicurity strategies on the economic crisis background

Annals of Spiru Haret University Economic Series, 2010
• The flexicurity concept – a combination of flexibility and security strategies, specific to each country – is a successful outcome[1] of the 2010 Lisbon Strategy.
Daniela PAŞNICU, Luise MLADEN
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Spleen Siliconoma

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Along with a silicone lymphadenitis in axillary lymph nodes there are few observations of siliconomas with other localization in the literature. We observed female patient of 34 years that had tumor mass in the spleen after 12 years from augmentation ...
Elena Alexandrovna Semenova, Anastasia A. Vasilkonova, Aminat U. Magomedova, Irina Borisovna Kaplanskaya, Maria Dmitrievna Sanatko, Mikhail M. Karpukhin, Alexander V. Grzhimolovsky, Lyubov S. Al-Radi   +7 more
doaj  

The Disaster Research Center at the University of Delaware:: The World's First Center for the Social Scientific Study of Disaster. [PDF]

Dela J Public Health, 2019
Cox Z, Kendra J, Wachtendorf T, Marlowe V.   +3 more
europepmc   +1 more source