Results 31 to 40 of about 12,028,240 (312)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Why Gender is a Relevant Factor in the Social Epistemology of Scientific Inquiry [PDF]
, 2002 In recent years, feminist philosophy of science has been subjected to criticism. Much of the debate has focused on the implications of the underdetermination thesis for accounts of the role of social values in scientific reasoning.
Rolin, Kristina
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
BMC Psychiatry, 2022 Background: Internalized stigma can have numerous negative effects on the well-being and employment of people with mental illness. Brief, valid, and reliable measures are needed to get a better understanding of self-stigmatization.
I. E. van Beukering +6 more
doaj +1 more source
RUDN Journal of Political Science, 2023 The aim of the research is to determine the possibilities and limitations of applying indices for assessing regional youth policy in the Russian Federation. The article contains a detailed analysis of domestic and foreign scientific literature on current
Sofia K. Kalashnikova, Irina I. Andriiv
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Correlations between Expenditure and Employees in R&D Activity by Performance Sectors from Romania [PDF]
Revista Română de Statistică, 2016 In the context of increased competition in the recent years, the innovation has become a key factor in economic development through better use of opportunities, capturing new markets and creating high quality jobs.
Vasilica Ciucă +3 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source