Results 91 to 100 of about 624,383 (304)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2013 This article presents a social-scientific and realistic interpretation of the parable of the Feast. The characteristics of a pre-industrial city are used to determine the realism of the parable.
Ernest van Eck
doaj
Social Criticism Da’wah Through Visual Works of @Terasdakwah During the COVID-19 Pandemic
Kalijaga Journal of CommunicationThis study aims to analyze the preaching message containing social criticism on the Instagram account @terasdakwah through a semiotic approach. The @terasdakwah account is a digital platform that actively spreads preaching content in a creative style ...
Farkhan Al Faiz, Akhmad Rifa'i
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Les fonctions de la critique dans la sociologie de Pierre Bourdieu
AstérionThe aim of this article is to restore the complexity and multiplicity of the functions of critique in Pierre Bourdieu’s sociology. The first function is a theoretical and scientific one that allows a Bachelardian-type of epistemological breakdown to be ...
Claude Gautier
doaj +1 more source
Of scheme paradigmatic for matrix epistemological: systematizing new levels of analysis [PDF]
ETD: Educação Temática Digital, 2014 At the moment there is a significant increase in scientific production sciences share (education, physical education and especial education) in terms of quantity, its quality becomes questionable.
Silva, Régis Henrique dos Reis +1 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Mission, identity and ethics in Mark: Jesus, the patron for outsiders
HTS Teologiese Studies/Theological Studies, 2013 In this contribution the relationship between mission, identity and ethics in Mark was investigated by means of a postcolonial and social-scientific reading, with a focus on patronage as a practice that constituted the main bond of human society in the ...
Ernest van Eck
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source