Results 51 to 60 of about 624,383 (304)

Area Studies in the Social Sciences [PDF]

Prostranstvennaâ Èkonomika
In the last decades, area studies have been subject to substantial criticism by the most mainstream social sciences. Area specialists are perceived as lacking the knowledge of modern research methodology and rather following the interests of humanities ...
Alexander Mikhailovich Libman
doaj   +1 more source

Karl Popper's Philosophical Breakthrough [PDF]

, 2004
Despite his well-known deductivism, in his early (unpublished) writings, Popper held an inductivist position. Up to 1929 epistemology entered Popper's reflections only as far as the problem was that of the justification of the scientific character of ...
Gattei, Stefano
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Le risque instrumentalisé ? Expertise scientifique et légitimité citoyenne : le cas de l’assainissement de la décharge industrielle de Bonfol en Suisse

VertigO, 2009
This article explores how social and scientific rationalities came into play in the context of the decontamination of the Bonfol (Switzerland) industrial dumping ground, and what consequences resulted from it.
Cecchini Amaranta
doaj   +1 more source

Social Criticism and the Exclusion of Ethics [PDF]

, 2008
As Axel Honneth has recently noted, the critical concerns of social philosophers during the past three decades have been focused primarily on questions of justice, with ethical issues about the human good being largely excluded.
Keat, Russell
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Unhiding the voices of women in the Parable of the Good Samaritan: A call for academic inclusion

Verbum et Ecclesia
The parables of Jesus are often susceptible to patriarchal, androcentric interpretations. By using a realistic reading and social-scientific criticism, this article will investigate the voices, roles, and presence of women in the parable of the Good ...
Charel D. du Toit
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source