Results 81 to 90 of about 9,772,075 (262)

President's Commission to Strengthen Social Security

open access: yes, 2001
info:ark/67531/metadc789On May 2, President Bush announced establishment of a bipartisan, 16-member Commission "to study and report specific recommendations to preserve Social Security for seniors while building wealth for younger Americans." The ...
President's Commission to Strengthen Social Security
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Pedagogia Social Comunitària: un model d’intervenció socioeducativa integral [PDF]

open access: yes, 2014
The current situation of social and economic instability affecting our society has revealed the existence of large pockets of people living in conditions of disadvantage or social exclusion.
Morata García, Txus
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Analogue Strategies and a Sense of Humour in the Learning of Social Competence on the Part of Social Education Professionals [PDF]

open access: yes, 2013
In this article we explore the development and initial results of an innovative methodology that uses metaphor and the participants’ sense of humour to create a narrative space in the context of university training in social competence that facilitates ...
Rosa i Gregori, Genoveva   +2 more
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Social Work Practice with Populations at Risk [PDF]

open access: yes, 1988
The University Archives has determined that this item is of continuing value to OSU's history.The Ohio State University College of Social WorkProceedings title page, table of contents, and ...
Ohio State University. College of Social Work
core  

Social Flow in Social MOOCs

open access: yes, 2015
Flow theory is a way to explain how humans can be self-motivated and reach a state of high focus and intense, very effective learning. Usually this theory is merely descriptive but recently it has also been operationalized and used as the basis for building autonomous agents.
openaire   +3 more sources

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