Results 111 to 120 of about 885,530 (314)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Sex differences in emotional concordance. [PDF]

, 2020
Emotions involve response synchronization across experiential, physiological, and behavioral systems, referred to as concordance or coherence. Women are thought to be more emotionally aware and expressive than men and may therefore display stronger ...
Liedlgruber, Michael, Mauss, Iris B, Rattel, Julina A, Wilhelm, Frank H   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Proceedings of the 3rd Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2015: advancing efficient methodologies through community partnerships and team science : Seattle, WA, USA. 24-26 September 2015. [PDF]

, 2016
Introduction to the 3rd Biennial Conference of the Society for Implementation Research Collaboration: advancing efficient methodologies through team science and community partnerships Cara Lewis, Doyanne Darnell, Suzanne Kerns, Maria Monroe-DeVita, Sara ...
Aarons, Gregory A, Arch, Joanna J, Barnett, Miya, Best, Helen, Borah, Elisa V, Bory, Christopher, Brookman-Frazee, Lauren, Bruns, Eric J, Campbell, Dayna, Carlson, Kathleen F, Carvalho, Michelle, Cevasco, Molly, Chamberlain, Patricia, Coldiron, Jennifer Schurer, Comtois, Katherine A, Cottrell, Erika K, Damschroder, Laura J, Damush, Teresa M, Darnell, Doyanne, Dondanville, Katherine, Dorsey, Caitlin, Dorsey, Shannon, Dwyer, Andrea, Ehrhart, Mark G, Fernandez, Maria E, Fizur, Phil, Franks, Robert P, Gamarra, Jennifer, Graham, Benjamin C, Green, Amy E, Gutner, Cassidy A, Hamilton, Alison, Hanson, Rochelle F, Hendricks, Karin, Heredia, Natalia I, Hernandez, Armando, Hook, Alyssa N, Jacobson, Nora, Jordan, Katelin, Karp, Zaher, Kegler, Michelle, Kellar-Guenther, Yvonne, Kerns, Suzanne, Kerns, Suzanne EU, Landes, Sara J, Lewis, Cara, Lewis, Cara C, Liang, Shuting Lily, Litz, Brett T, Locke, Jill, Lovejoy, Travis L, Lowery, Julie C, Lucenko, Barbara, Lyon, Aaron R, Marriott, Brigid, Marriott, Brigid R, McCaughan, Stacey Young, Miech, Edward J, Mintz, Jim, Mitchell, Jill L, Molino, Alma, Monroe-DeVita, Maria, Moreland, Angela, Negrete, Andrea, Ono, Sarah S, O’Neil, Maya E, O’Sullivan, Patricia, Palinkas, Lawrence A, Pandhi, Nancy, Pavelle, Bridget, Peterson, Alan L, Pierson, Andria, Pullmann, Michael D, Puspitasari, Ajeng, Regan, Jennifer, Resick, Patricia A, Resnick, Heidi S, Risendal, Betsy, Satre, Derek, Satterfield, Jason, Saunders, Benjamin E, Schreiter, Elizabeth Zeidler-, Scott, Kelli, Serrano, Neftali, Stadnick, Nicole, Stanick, Cameo, Stirman, Shannon Wiltsey, Suvak, Michael, Trott, Elise M, Uomoto, Jacqueline A, Velasquez, Susan, Vogt, Dawne, Wachen, Jennifer Schuster, Wamsley, Maria, Wietfeldt, Natalie, Willging, Cathleen E, Woolf, Nicholas H, Yarvis, Jeffrey S, Young, Vicki, Yuan, Patrick   +99 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Trajectories of school absenteeism in adolescents with recurrent pain: predictors and distal outcomes

PAIN Reports
. Introduction:. A sizeable number of adolescents with recurrent pain frequently miss school, yet the trajectories of absenteeism and their correlates remain unclear.
Christiana Owiredua, Ida Flink, Brittany Evans, Katja Boersma   +3 more
doaj   +1 more source

Hope Measurement in Mexican American Youth [PDF]

, 2007
Hope is a motivational construct that has been associated with many positive outcomes in children, adolescents, and adults. Although research with the Children’s Hope Scale (CHS) has demonstrated support for the reliability and validity of the CHS with ...
Edwards, Lisa, Lopez, Shane J., Ong, Anthony D.   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source