Results 151 to 160 of about 885,530 (314)

Implementing LGBTQ-affirmative CBT: study protocol for an effectiveness-implementation trial at 90 LGBTQ community centers

BMC Health Services Research
Background Sexual and gender minorities (SGM) experience among the largest mental health disparities of any population. One driver has been the lack of evidence-based practices (EBPs) addressing the distinct mechanisms underlying SGM’s risk.
John E. Pachankis, Danielle Chiaramonte, Hunter T. Baldwin, Corey Prachniak, Deborah S. Levine, Shawn Van, Rebekah J. Hobbs, Hadley Ankrum, Lauren J. Wilkins, Tyler D. Harvey, Audrey Harkness, Skyler D. Jackson, Em Matsuno, Zachary A. Soulliard, Briana S. Last, Julian Burger, Molly Delehant, Xin Zhou, Ashley K. Hagaman, Dennis H. Li, Brian Mustanski   +20 more
doaj   +1 more source

The Pandemic as a Portal: Reimagining Psychological Science as Truly Open and Inclusive Postdoctoral Associate Assistant Professor of Communication & Social Behavior Associate Professor Assistant Professor Professor Post Doctoral Researcher Assistant Professor of Psychology

Psychological science is at an inflection point: The COVID-19 pandemic has already begun to exacerbate inequalities that stem from our historically closed and exclusive culture. Meanwhile, reform efforts to change the future of our science are too narrow in focus to fully succeed. In this paper, we call on psychological scientists—focusing specifically
Alison Ledgerwood, Sa-kiera Tiarra Jolynn Hudson, Neil Lewis, Jr., Keith Maddox, Cynthia Pickett, Jessica Remedios, Sapna Cheryan, Amanda B. Diekman, Natalia Bezerra Dutra, Jin X. Goh   +9 more
openaire   +1 more source

The Genetic Foundations of Attitude Formation: The Case of Left-Right Political Orientations [PDF]

, 2014
Kandler C, Bell E, Shikishima C, Yamagata S, Riemann R. The Genetic Foundations of Attitude Formation: The Case of Left-Right Political Orientations. In: R. A. S, S. M. K, eds.
Bell, Edward, Kandler, Christian, R. A., Scott, Riemann, Rainer , S. M., Kosslyn, Shikishima, Chizuru, Yamagata, Shinji   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

TOP 2025: An Update to the Transparency and Openness Promotion Guidelines Research Associate Professor Assistant Professor in Social & Behavioral Sciences Behavioral and Social Scientist Faculty Associate Professor Assistant Professor Assistant Professor Director of Policy Initiatives Citizen Science Project Coordinator, VA Master Naturalists Director of Advising Associate Professor of Psychological Science Doctoral Candidate Research Fellow Assistant professor

Open science remains vital to the progress and functioning of the global research enterprise. Published in 2015, the Transparency and Openness Promotion Guidelines (TOP 2015) was developed as a policy framework to enhance the verifiability of empirical research claims in journal articles.
Sean Grant, Katherine S. Corker, David Thomas Mellor, Suzanne L. K. Stewart, Aidan Cashin, Malgorzata Lagisz, Evan Mayo-Wilson, David Moher, Daniel Umpierre, Virginia Barbour   +9 more
openaire   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Profiles of psychopathology and quality of life in individuals with recent displacement experiences: a latent profile analysis

BMC Public Health
Background Mental health conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD) are highly prevalent among forcibly displaced populations. Prevalence rates of common mental health conditions have been studied in refugee groups.
M. Ali Amiri, Gerhard Andersson, Kristofer Vernmark, Anna Leiler, Anna Bjärtå   +4 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source