Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Psychology for Economists [PDF]
Orthodox economics focuses on the analysis of the way the economic force or motivation operates, thereby abstracting from the functioning of other primary forces or motivations, such as the social and the psychic motivation.
Piet Keizer
core
Open science remains vital to the progress and functioning of the global research enterprise. Published in 2015, the Transparency and Openness Promotion Guidelines (TOP 2015) was developed as a policy framework to enhance the verifiability of empirical research claims in journal articles.
Sean Grant +9 more
openaire +1 more source
To Whom National Culture Matters: An Analysis of Mentions of Countries in Titles and Abstracts in Social and Personality Psychology and Related Fields From 1990 to 2020. [PDF]
de Almeida I +4 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
This document contains the original and the subsequent responses to the proposed establishment of a Regular Clinical Track Faculty in the College of Social and Behavior ...
Ohio State University. College of Social and Behavioral Sciences
core +1 more source
Reply to Hamilton and Konvalinka: Distinguishing behavioral similarity from dyadic neural-state dynamics in hyperscanning. [PDF]
Zhang P, Yang X, Jiang Y, Guo C.
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
T-ScEmo4ALL Plus+: Treatment for social cognition disorders in patients with acquired brain injury and neuropsychiatric problems - A single case experimental design (SCED) study protocol. [PDF]
Raafs B +4 more
europepmc +1 more source

