Results 151 to 160 of about 23,262,902 (306)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Psychology for Economists [PDF]

open access: yes
Orthodox economics focuses on the analysis of the way the economic force or motivation operates, thereby abstracting from the functioning of other primary forces or motivations, such as the social and the psychic motivation.
Piet Keizer
core  

TOP 2025: An Update to the Transparency and Openness Promotion Guidelines Research Associate Professor Assistant Professor in Social & Behavioral Sciences Behavioral and Social Scientist Faculty Associate Professor Assistant Professor Assistant Professor Director of Policy Initiatives Citizen Science Project Coordinator, VA Master Naturalists Director of Advising Associate Professor of Psychological Science Doctoral Candidate Research Fellow Assistant professor

open access: yes
Open science remains vital to the progress and functioning of the global research enterprise. Published in 2015, the Transparency and Openness Promotion Guidelines (TOP 2015) was developed as a policy framework to enhance the verifiability of empirical research claims in journal articles.
Sean Grant   +9 more
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Proposal to Establish Clinical/Practitioner Faculty Track in the College of Social and Behavioral Sciences

open access: yes, 2007
This document contains the original and the subsequent responses to the proposed establishment of a Regular Clinical Track Faculty in the College of Social and Behavior ...
Ohio State University. College of Social and Behavioral Sciences
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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