Results 161 to 170 of about 141,885 (309)

A history of 'relevance' : South African psychology in focus

, 2013
Includes abstract.Includes bibliographical references.This thesis investigates the historical and discursive contours of the "relevance" debate in South African psychology. It begins by contextualizing the debate, detailing how appeals for "relevance" in
Long, Wahbie
core  

Implementing LGBTQ-affirmative CBT: study protocol for an effectiveness-implementation trial at 90 LGBTQ community centers

BMC Health Services Research
Background Sexual and gender minorities (SGM) experience among the largest mental health disparities of any population. One driver has been the lack of evidence-based practices (EBPs) addressing the distinct mechanisms underlying SGM’s risk.
John E. Pachankis, Danielle Chiaramonte, Hunter T. Baldwin, Corey Prachniak, Deborah S. Levine, Shawn Van, Rebekah J. Hobbs, Hadley Ankrum, Lauren J. Wilkins, Tyler D. Harvey, Audrey Harkness, Skyler D. Jackson, Em Matsuno, Zachary A. Soulliard, Briana S. Last, Julian Burger, Molly Delehant, Xin Zhou, Ashley K. Hagaman, Dennis H. Li, Brian Mustanski   +20 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Confidence Intervals for Standardized Effect Sizes: Theory, Application, and Implementation

The behavioral, educational, and social sciences are undergoing a paradigmatic shift in methodology, from disciplines that focus on the dichotomous outcome of null hypothesis significance tests to disciplines that report and interpret effect sizes and ...
Ken Kelley
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Artificiality in Social Sciences

This text provides with an introduction to the modern approach of artificiality and simulation in social sciences. It presents the relationship between complexity and artificiality, before introducing the field of artificial societies which greatly ...
Rennard, Jean-Philippe
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Detecting and preventing financial abuse of older adults: Examining decision making by health, social care and banking professionals

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Financial elder abuse is gaining increasing attention from researchers and policy makers.
Davies, Miranda Louise
core  

Relationship among temporary separation, attachment styles, and adjustment in first-grade Iranian children

Psychology Research and Behavior Management, 2016
Siyamak Tahmasebi,1 Saman Mafakheri Bashmaq,2 Mansoureh Karimzadeh,3 Robab Teymouri,4 Mahdi Amini,5 Maryam Sadat M vaghefi,6 M Ali Mazaheri7 1Department of Preschool Education, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran ...
Tahmasebi S, Mafakheri Bashmaq S, Karimzadeh M, Teymouri R, Amini M, vaghefi MSM, Mazaheri MA   +6 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source