Results 141 to 150 of about 10,171,208 (347)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Social Inclusion of Immigrant Irish Primary School Children: Urbanicity, School Size and School Composition

Social Sciences
Given world immigration patterns, understanding immigrant children’s social inclusion is crucial, especially the role of school characteristics.
Martin H. Jones, Jennifer E. Symonds, Neil Kaye, Seaneen Sloan, Dympna Devine, Gabriela Martinez Sainz, Olga Ioannidou   +6 more
doaj   +1 more source

Social Values in Risk Acceptance [PDF]

, 1975
Section I outlines the general structure of risk assessment, and in Section II the process of risk assessment as applied to technological systems, such as energy systems, is discussed.
Linnerooth, J., Otway, H.J., Pahner, P.D.   +2 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Relationship of Rejection Sensitivity to Depressive Symptoms in Adolescence: The Indirect Effect of Perceived Social Acceptance by Peers. [PDF]

Behav Sci (Basel), 2023
Giovazolias T.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Do TV Watching and Gaming Affect Adolescents’ Social Acceptance Among Classmates?

Youth
Social acceptance among peers is an important predictor of adolescents’ academic and social outcomes. This study investigates how social acceptance depends on adolescents’ engagement in watching TV and gaming. Based on Contact Theory, we expected that TV
Verena Hofmann, Ryan O. Kellems, Donato Lucek, Christoph M. Müller   +3 more
doaj   +1 more source

Socially (un)acceptable [PDF]

, 2009
Access to social media sites via public libraries is patchy in Scotland, says Christine Rooney-Browne, and it’s time to bring them all into the world of shared communities.
openaire  

Socially Acceptable CO2 Prices

Wirtschaftsdienst, 2022
Abstract This article considers the conditions under which a carbon tax or other CO2 emissions pricing mechanisms can be seen as “socially balanced” and the appropriate economic policy instruments to achieve this goal. A broad set of instruments should be used that not only address relative price changes in the consumption basket but also potential job
Sebastian Dullien, Ulrike Stein
openaire   +1 more source