Results 151 to 160 of about 19,124,510 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effect of Social Activity on All-Cause Dementia Among South Korean Elders: A Retrospective Cohort Study. [PDF]

Health Sci Rep
Jeong W, Jeong W, Kim S.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study. [PDF]

BMC Med
Zhang Y, Zhou Y, Kivimäki M, Holt-Lunstad J, Carrillo-Larco RM, Xu X.   +5 more
europepmc   +1 more source

Intensive longitudinal assessment of mobility, social activity and loneliness in individuals with severe mental illness during COVID-19. [PDF]

Schizophrenia (Heidelb), 2023
Valeri L, Rahimi-Eichi H, Liebenthal E, Rauch SL, Schutt RK, Öngür D, Dixon LB, Onnela JP, Baker JT.   +8 more
europepmc   +1 more source

Cognitive activity mediates the association between social activity and cognitive performance: A longitudinal study.

Psychology and Aging, 2016
Cassandra L. Brown, Annie Robitaille, E. Zelinski, R. Dixon, S. Hofer, A. Piccinin   +5 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Late-life social activity and subsequent risk of dementia and mild cognitive impairment. [PDF]

Alzheimers Dement
Chen Y, Grodstein F, Capuano AW, Wang T, Bennett DA, James BD.   +5 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Critical reflections on the impact of late-life social activity on dementia and mild cognitive impairment (MCI). [PDF]

Alzheimers Dement
Liu S, Ma J.
europepmc   +1 more source