Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Does access to cardiac investigation and treatment contribute to social and ethnic differences in coronary heart disease? Whitehall II prospective cohort study [PDF]
Objective: To determine whether access to cardiac procedures and drugs contributes to social and ethnic differences in coronary heart disease in a population setting. Design: Prospective study with follow up over 15 years.
Britton, A. +3 more
core
Although organized activities (OAs) have been established as important contexts of development, limited work has examined the role of OAs across the high school transition in buffering adolescents' social adjustment by providing opportunities for ...
Amy M Bohnert, J. Aikins, Nicole Arola
semanticscholar +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The health effects of forced retirement on older New Zealanders :|ba thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University, Palmerston North, New Zealand [PDF]
This study investigated the relationship between forced retirement and physical and mental health of older New Zealanders. As well, individuals’ social support, socioeconomic status, and participation in employment and voluntary and recreational ...
Crookes, Nancey Jane
core
Infant massage and quality of early mother-infant interactions: Are there associations with maternal psychological wellbeing, marital quality, and social support? [PDF]
Infant massage programs have proved to be effective in enhancing post-natal development of highly risk infants, such as preterm newborns and drug or HIV exposed children.
BOZZA, GIUSY +4 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Łuczyk Marta, Pietraszek Agata, Łuczyk Robert, Stanisławek Andrzej, Szadowska-Szlachetka Zdzisława, Charzyńska‑Gula Marianna. Akceptacja choroby w grupie kobiet leczonych chirurgicznie z powodu nowotworu piersi = Illness acceptance among women who have ...
Marta Łuczyk +5 more
doaj
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The article focuses on the impact that socio-cultural differences had on the social adjustment of foreign students through their years of attending universities in the USSR/Russia.
C. . Ichaka
doaj

