Results 101 to 110 of about 1,488,006 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Effectiveness of Group Training of Concepts of Choice Theory on Cognitive Emotional Regulation Strategies and Social Adjustment in HIV-Positive Prisoners

open access: yesمجله علوم روانشناختی, 2022
Background: HIV infection is a new social phenomenon that affects almost all aspects of a person’s mental, physical, social and economic health in life.
Reza Mirzaei   +3 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Early Adolescents and Exposure to Risks Online: What Is the Role of Parental Mediation Styles?

open access: yesSocial Sciences
Studies indicate that early adolescents are exposed to several online risks. Furthermore, early adolescents with Special Educational Needs (SENs) often experience emotional, social, or family difficulties, which increase their vulnerability to online ...
Clara Cavallini   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Contribution of Emotional Intelligence, Coping, and Social Support towards Adjustment and Academic Achievement amongst Fresh Students in the University [PDF]

open access: yes, 2008
Adjustment is a significant predictor of academic achievement amongst fresh students in university. Adjustment problems can affect the students’ performance if they are not overcome.
Abdullah, Maria Chong
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The effectiveness of teaching emotion-based processing strategies on academic stress, social adjustment and psychological distress of high school male students [PDF]

open access: yesمجله علوم روانشناختی
Background: Studies have shown that the experience of emotions in educational environments affects academic stress, social adjustment and psychological distress. The basic experiential processing method under the title of emotion-oriented processes leads
kianoosh beyranvand   +3 more
doaj  

Examining the role of perceived social support on psychological adjustment of international students in a Malaysian public university [PDF]

open access: yes, 2010
The globalization of the economy and society has had its impact on Malaysian higher education institutions, particularly universities. The Malaysian Ministry of Higher Education aims at intensifying globalization through increasing the number of ...
Chelliah, Shankar   +2 more
core  

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