Results 91 to 100 of about 13,017,750 (257)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Aid tying and donor fragmentation [PDF]
This study tests two opposing hypotheses about the impact of aid fragmentation on the practice of aid tying. In one, when a small number of donors dominate the aid market in a country, they may exploit their monopoly power by tying more aid to purchases ...
Smets, Lodewijk, Knack, Stephen
core
Time at home. Analysis of a day centre as a place of care for women experiencing severe precarity
Brussels StudiesThis article examines the role of spatial arrangements in care relations within a day centre for women experiencing severe precarity and/or homelessness in the Brussels-Capital Region.
Susan Even
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
BelletenThis article compares paid prayer workers employed in the Ottoman Empire and England during the sixteenth and seventeenth centuries. Throughout history, clergy in all societies undertook the duty of offering prayers.
Songül Şenlik
doaj
Social Context and Hearing Aid Adoption
Trends in Hearing, 2016 Hearing rehabilitation tends to focus on the influence of intraindividual factors and concepts such as readiness for change and health beliefs. In contrast, less is known about the role of social context and the potential role of significant others on ...
Gurjit Singh, Stefan Launer
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Does Aid Matter? Measuring the Effect of Student Aid on College Attendance and Completion [PDF]
Does student aid increase college attendance or simply subsidize costs for infra-marginal students? Settling the question empirically is a challenge, because aid is correlated with many characteristics that influence educational investment decisions.
Susan M. Dynarski
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Gender factors of social anxiety in adolescence [PDF]
Психологическая наука и образование (2007. Online), 2014 Social anxiety in adolescence is one of the most important factors of social and psychological maladjustment. The data of Russian and international research of the differences in the severity of social anxiety in boys and girls is not uniform. In a study
Pavlova T.S., , Kholmogorova A.B.
doaj