Results 101 to 110 of about 1,787,877 (302)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Protection of cultural rights of the vulnerable groups: international legal aspects

open access: yesRUDN Journal of Law, 2013
The article analyzes the cultural human rights. It is reported that the States today shall not only protect cultural rights in general, but also shall pay special attention to protecting the cultural rights of vulnerable groups (women, children, elderly,
N V Volkova
doaj  

Analysis of the Challenges and Dilemmas in the Categorization of Economic, Social and Cultural Rights

open access: yesمجلة الآداب
This paper discusses the limitations associated with the basic classification of human rights into several categories. The topic of whether international trends have an impact on the State's view of the significance of implementing rights through the ...
Bimbo OGUNBANJO
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

International legal protection of cultural rights of vulnerable groups: some specific aspects

open access: yesRUDN Journal of Law, 2012
The article analyzes the cultural rights. It is reported that the States today shall not only protect cultural rights in general, but also shall pay special attention to protecting the cultural rights of vulnerable groups (women, children, elderly ...
E A Kukin
doaj  

Tensions and Challenges in Relation to the Enforceability of Economic, Social, and Cultural Rights in Argentina in the Light of Recent Events

open access: yesRevista Latinoamericana de Derechos Humanos, 2018
This paper problematizes around the myths and truths of civil and political rights, and of economic, social, and cultural rights, especially with regard to their legal enforceability. To do this, the article takes a normative approach to how both "groups"
Agustina Pérez
doaj   +1 more source

A human rights approach to the economic analysis of bureaucratic corruption [PDF]

open access: yes
The traditional arena of human rights discourse and practice made little or no allowance for the rapidly growing international phenomenon of bureaucratic corruption.1 In the recent past, states have consistently maintained that bureaucratic corruption ...
Ifediora, John
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Cultural rights in the Republic of Serbia: Current state and perspectives [PDF]

open access: yesStrani pravni život, 2019
Cultural rights are one of the least developed groups of human rights. It is very controversial which rights are included in cultural rights. However, despite their vagueness, their importance is increasing today.
Nikolić Aleksa D.
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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