Results 71 to 80 of about 109,115 (256)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Protection of cultural rights of the vulnerable groups: international legal aspects
RUDN Journal of Law, 2013 The article analyzes the cultural human rights. It is reported that the States today shall not only protect cultural rights in general, but also shall pay special attention to protecting the cultural rights of vulnerable groups (women, children, elderly,
N V Volkova
doaj
مجلة الآدابThis paper discusses the limitations associated with the basic classification of human rights into several categories. The topic of whether international trends have an impact on the State's view of the significance of implementing rights through the ...
Bimbo OGUNBANJO
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
International legal protection of cultural rights of vulnerable groups: some specific aspects
RUDN Journal of Law, 2012 The article analyzes the cultural rights. It is reported that the States today shall not only protect cultural rights in general, but also shall pay special attention to protecting the cultural rights of vulnerable groups (women, children, elderly ...
E A Kukin
doaj
Cultural rights in the Republic of Serbia: Current state and perspectives [PDF]
Strani pravni život, 2019 Cultural rights are one of the least developed groups of human rights. It is very controversial which rights are included in cultural rights. However, despite their vagueness, their importance is increasing today.
Nikolić Aleksa D.
doaj
Revista Latinoamericana de Derechos Humanos, 2018 This paper problematizes around the myths and truths of civil and political rights, and of economic, social, and cultural rights, especially with regard to their legal enforceability. To do this, the article takes a normative approach to how both "groups"
Agustina Pérez
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source