Results 81 to 90 of about 20,143,172 (287)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Applied Informatics and ComputingThe rapid growth of social media in Indonesia has given rise to social phenomena such as Fear of Missing Out (FOMO). Expressions of FOMO on platforms like X (previously Twitter) often written informally, filled with abbreviations, slang, and emotional ...
Nadhif Fauzil Adhim, Nuri Cahyono
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Automatic Image Annotation and Object Detection
We live in the midst of the information era, during which organising and indexing information more effectively is a matter of essential importance. With the fast development of digital imagery, how to search images - a rich form of information - more ...
Tang, Jiayu
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
National Child Care Information: final report on options for systems development and implementation
, 2002 This report addresses the final phase of the Consultancy Project on National Child Care Information (Phase IV). This consultancy was commissioned by the Steering Group on Child Care Information which was established by the Department of Health and ...
Social Information Systems Ltd
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A Correlation Approach for Automatic Image Annotation
, 2006 The automatic annotation of images presents a particularly complex problem for machine learning researchers. In this work we experiment with semantic models and multi-class learning for the automatic annotation of query images.
Szedmak, S. +7 more
core +2 more sources