Results 91 to 100 of about 13,395,620 (282)

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Mechanisms of Action in the Treatment of Social Anxiety Disorder

, 2014
Treatment outcome studies for social anxiety disorder have provided consistent evidence for the efficacy of two modalities of treatment: cognitive behavioral therapy (CBT) and pharmacotherapy.
Otto, Michael W, Safren, Steven A, Hearon, Bridget A, Michael W. Otto, Steven A. Safren, Bridget A. Hearon   +5 more
core   +1 more source

Pharmacological Treatment of Social Anxiety Disorder

, 2013
Social anxiety disorder (social phobia) is a common and typically long-standing medical condition, characterized by an excessive fear of being observed or evaluated negatively in social or performance situations. Efficacious interventions in acute treatment include cognitive behavioural therapy and a range of medications including many antidepressants,
Masdrakis, V.G., Turic, D., Baldwin, D.S.   +2 more
openaire   +3 more sources

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology

, 2014
This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and clinical management, including recognition, acute ...
den Boer, J.A., Fineberg, N.A., Bandelow, B., Davies, S., Nutt, David J, Wee, N. van der, Fineberg, Naomi, Scott, Jan, O'Neill, C., Anderson, I.M., Nutt, D.J., O’Neill, C., Scott, J., Allgulander, Christer, Christmas, D.M., Christmas, David M, Fineberg, N., Davies, Simon, Allgulander, C., Anderson, Ian M., McCrone, P., Wittchen, H-U, Christmas, David M., van der Wee, N., Anderson, Ian M, Malizia, A., Nutt, David J., O'Neill, Catherine, Baldwin, D.S., Lidbetter, N., Lidbetter, Nicky, Bandelow, Borwin, Nabarro, Daniel, Malizia, Andrea, McCrone, Paul, van der Wee, Nic, Wittchen, Hans-Ulrich, Baldwin, David S., Baldwin, David S, den Boer, Johan A, Nabarro, D., Boer, J.A. den, Wittchen, H.U., Fineberg, Naomi A., den Boer, Johan A.   +44 more
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Self-processing characteristics from first-person and third-person perspectives in individuals with social anxiety disorder: insights into negative bias

Frontiers in Psychiatry
BackgroundAs one of the most common psychological problems, social anxiety disorder (SAD) has lots of negative effects on the physical and mental development of individuals, such as decreasing the quality of interpersonal relationships, and even causing ...
Huating Wu, Caizhen Yue, Fasheng Cao, Yihong Long, Yihong Long, Yan Wang, Yan Wang   +6 more
doaj   +1 more source

Social anxiety disorder: A review of environmental risk factors

Neuropsychiatric Disease and Treatment, 2008
Christina A Brook, Louis A SchmidtDepartment of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Ontario, CanadaAbstract: Social anxiety disorder (SAD) is a debilitating and chronic illness characterized by persistent fear of one or
Christina A Brook, Louis A Schmidt
doaj  

The efficacy of intensive short-term dynamic psychotherapy (ISTDP) on self-esteem, emotion regulation, and defense mechanisms in men with social anxiety disorder

مجله علوم روانشناختی, 2022
Background: Social Anxiety Disorder is considered as the most common disorder among the anxiety disorders that causes various psychological problems. Therefore, it is important to investigate the effective therapeutic interventions in order to reduce ...
Kamal Mehboodi, Nuralla Mohammadi, Changiz Rahimi, Mehdi Reza Sarafraz   +3 more
doaj  

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source