Results 111 to 120 of about 13,395,620 (282)
Neuropsychiatric Disease and Treatment, 2022 Ya-Song Luan,1 Gao Zhan-ling,1 Li Mi,1 Liu Ying,2 Bai Lan,1 Li Tong1 1Department of Nursing Science, Shandong Traditional Chinese Medicine College, YanTai, People’s Republic of China; 2Department of Neurosurgery, YanTai Affiliated Hospital of Binzhou ...
Luan YS +5 more
doaj
Advanced Science, EarlyView.Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren +11 more
wiley +1 more source
Dopamine and social anxiety disorder [PDF]
Revista Brasileira de Psiquiatria, 2006 Robinson, Hayley M +3 more
openaire +3 more sources
Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring
Advanced Science, EarlyView.Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen +6 more
wiley +1 more source
Advanced Science, EarlyView.Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami +7 more
wiley +1 more source
The impact of blushing propensity on functional impairment in individuals with social anxiety disorder [PDF]
, 2011 Magister Psychologiae - MPsychThe propensity to blush is typical of many individuals with social anxiety disorder (SAD). SAD is also associated with significant disability or functional impairment.
Fell, Bryony
core
Frontiers in PsychiatryBackgroundSocial anxiety disorder imposes impacts of functional disability, poor educational achievement, loss of work productivity, social impairment, greater financial dependency, and impairment in quality of life.
Yadeta Alemayehu +8 more
doaj +1 more source
Beyond Probiotics: Postbiotics for Healthy Aquaculture
Advanced Science, EarlyView.This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas +12 more
wiley +1 more source
Antiepileptic Drugs in the Treatment of Anxiety Disorders [PDF]
Psikiyatride Güncel Yaklaşımlar, 2009 In addition to epilepsy, antiepileptic drugs are used in neurologic conditions such as chronic pain and in the treatment of bipolar disorder in psychiatry. There are studies reporting its use in the treatment of anxiety disorders.
Levent Mete +2 more
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PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source