Results 51 to 60 of about 5,383,703 (281)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2014 Our project was focused on the investigation of attitudes and preferences of the rural population concerning landscape protection and use in the context of land use planning documentations – Land Consolidations (LC) and Land Use Planning (LUP).
Petr Karásek +2 more
doaj +1 more source
Some Aspects of Social Farming in Czechia
European Countryside, 2022 Social farming (SF) has been developing dynamically in the Czech Republic in the last 10 years and enterprises are emerging and operating where the necessary conditions and environment are created for various people from target groups.
Chovanec Tomáš +2 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis of life quality development in the administrative districts of South Moravia
Agricultural Economics (AGRICECON), 2008 : The equable regional development and mitigation of disparities among the individual regions are main objectives of regional policy not only in the Czech Republic but in the whole European Union.
I. Živělová, J. Jánský
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Aspects of social identity, self concept, self esteem, self functioning and gender aspects (part 4) [PDF]
, 2012 Formation of self concept begins in childhood and it continues throughout an individual’s life. Like Eric Erikson says in his „Eight stages of development‟, an individual goes through eight stages in his ...
Yahaya, Azizi
core +16 more sources
, 2009 Contains fulltext : 75842.pdf (Publisher’s version ) (Open Access)
Bijker, W. +5 more
openaire +2 more sources