Results 111 to 120 of about 7,401,341 (346)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Suburban Sustainability in Budapest Agglomeration—The Case of Törökbálint

Sustainability
The rapid growth of the metropolitan area around Budapest has led to increased traffic, infrastructure problems, and social and economic issues in the suburbs, making the sustainability of these areas a key topic in professional and public discussions ...
J. B. Kocsis, Kyra Tomay
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Risk Assessment and Sustainable Development: Towards a Concept of Sustainable Risk [PDF]

, 1997
Dr. Mehta examines two dominant approaches for managing health and environmental risks and suggests that they would better serve if ...
Mehta, Michael D.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Social cohesion in the Russian society: Results of the empirical study

RUDN journal of Sociology
The article presents the results of the study of the perception of social cohesion in today’s Russia. The study consisted of two stages - expert and all-Russian - and was conducted with methods of expert assessments, focus groups and online survey in ...
V. A. Tupikova, E. K. Misiautova, L. E. Murzikov   +2 more
doaj   +1 more source

Performance Evaluation of Common Rail Direct Injection (CRDI) Engine Fuelled with Uppage Oil Methyl Ester (UOME) [PDF]

, 2015
For economic and social development of any country energy is one of the most essential requirements. Continuously increasing price of crude petroleum fuels in the present days coupled with alarming emissions and stringent emission regulations has led to ...
Banapurmath, N. R. (N), Basavarajappa, D. N. (D), Khandal, S. V. (S), Manavendra, G. (G)   +3 more
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Smartness. The face of the integration in the new “performing” society [PDF]

, 2018
Economia, potere, così come case, persone e lavoro, ma prima di ogni altra cosa città: tutto negli ultimi anni è chiamato a diventare “smart”. È questa l’era della smart economy, della smart governance, della smart home, delle smart people, dello smart
Iannone, Roberta
core  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source